The present work gives preliminary results of analysis of drug mixtures (NEPHROSAL tea bag) and its water infusion. In a sample of dried drugs the elements K, Ca, Mn, Fe, Ni, Cu, Zn, Br, Rb, Sr, Pb were identified, whereas in their water infusion only Ca, Mn, Zn and Sr were found. The method applied was radionuclide X-ray fluorescence analysis using a radionuclide source109Cd, a Si/Li semiconductor detector and a multichannel analyzer Canberra 8100.
Authors:E. Havránek, A. Bumbálová, M. Beláková, M. Komová, and P. Křenek
In this paper, the labeling characteristics and biological behavior of five aminopolycarboxylic acid derivatives have been studied: N-(phosphonomethyl) nitrilodiacetic acid (99mTc-MPIDA), N,N-(diphosphono) aminoacetic acid (99mTc-GDP), N-(2-carbamoylethyl) nitrilodiacetic acid (99mTc-KEIDA), N-(2,3-dihydroxypropyl) nitrilodiacetic acid (99mTc-DPKA), 2-[N-(2-hydroxyethyl)-N-carboxymethyl] aminopropanoic acid (99mTc-EAPA).
Authors:A. Bumbálová, A. Pikulíková, M. Komová, and A. Muchová
Determination of Cr, Fe, Cu, Zn and Pb in drinking water preconcentrated on a chelating ion exchanger of Czechoslovak production is described. The analytical system consisted of a radionuclide source238Pu, a Si/Li semiconductor detector and a multichannel analyzer. Results are compared with trehshold limit values recommended for drinking water.
Authors:E. Havránek, A. Bumbálová, P. Křenek, M. Strašák, M. Beláková, and M. Komová
The preparation of99mTc-Sn-EBV and99mTC-Sn-EBA is described. Different parameters affecting the labeling efficiency (ligand concentration, pH, molar ligand: reducing agent ratio) as well as the time-dependent stability of labeled compounds were investigated. Preliminary biodistribution studies in Wistar rats showed accumulation of the above mentioned compounds in kidneys.
Authors:E. Havránek, A. Bumbálová, M. Komová, M. Beláková, P. Butvin, and V. Kettmann
A series of bidentate and tetradentate ligands with azomethine and Ar–OH functional groups derived from salicylaldehyde and primary alkyl or aryl monoamines and diamines has been synthesized and labeled with99mTc at various pH's using stannous chloride as reducing agent. The labeling efficiency was monitored by thin layer and paper chromatography.