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  • Author or Editor: M. Lázníček x
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Abstract  

Radiolabeling, stability and pharmacokinetic analysis in rats of 111In-DOTA-Tyr3-octreotate were studied. Radiolabeling of the peptide is simple and high radiolabeling yields were achieved. The agent was stable in in vivo conditions, the radioactivity eliminated by urine was nearly completely in the parent form. The affinity of 111In-DOTA-Tyr3-octreotate to somatostatin receptor-rich organs was substantially higher than that of commercially available 111In-DTPA-octreotide (OctreoScan). The study confirmed high in vivo affinity of the peptide to somatostatin receptors and revealed that receptor binding alters both distribution profile and elimination pathways of the agent in preclinical experiments.

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Abstract  

The synthesis of cyanoferrates of quadrivalent metals and the sorption of caesium ions by these materials have been studied. It has been found that the compositions of the compounds and their properties are strongly influenced by the degree of hydrolysis of the metal. These is no sorption of caesium by Zr4+ and Th4+ cyanoferrates, while the compounds of oxygencontaining bivalent complex cations exhibit behaviour similar to that of the other bivalent metals. The sorption of caesium by (TiO)2R is govermed by an ion-exchange mechanism; with (ZrO)2R changes occur in the crystal lattice, and (ThO)2R exhibits a low affinity towards caesium.

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