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  • Author or Editor: M. Mushtaq x
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Abstract  

Adsorption behavior of molybdate on acidic alumina was studied at boiling water bath temperature (~100 °C). Various parameters affecting the adsorption of molybdenum, such as pH, amount of molybdenum, incubation period, etc., were determined. A 99mTc generator was prepared by adsorbing low specific activity 99Mo (150 mg) on 1 g alumina. Elutions were carried out with saline. Performance of the generator such as 99Mo breakthrough, aluminum contents, pH, elution profile, radiochemical purity, and labeling efficiency of kits were checked.

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Abstract  

No-carrier-added 90Y was separated from 90Sr via colloid formation of 90Y in basic media. The mixture was passed through glass wool or membrane filter. The filtrate contained 90Sr, while 90Y was retained on glass wool/membrane filter. Yttrium-90 was extracted with 0.1 M HCl. Contamination of 90Sr was <0.0001%. More than 98% labeling yield of 90Y-EDTMP was confirmed by paper chromatography.

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Abstract  

The synthesis of 188Re-MAG3 is described using 188Re, which was obtained from the alumina based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-MAG3 on reducing agent concentration, Bz-MAG3 concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-MAG3 was 98%. TLC and HPLC techniques were employed to monitor the different species formed. Biodistribution study of 188Re-MAG3 was carried out in rats and compared with behavior of 99mTc-MAG3.

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Abstract  

Hydroxyapatite (HA), a natural constituent of bone, was synthesized. HA particles were radiolabeled with 188Re. Radiolabeling efficiency was 95%. In vitro studies showed 5% loss of activity from particles in normal saline over a period of 2 days, whereas a dissociation rate of 9% was observed in human serum albumin.

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Abstract  

Sorption of Cd and Ag by a cation exchange resin has been studied at different molarities of nitric acid. The sorption capacity of Cd on a cation exchanger has been determined. A109Cd/109mAg generator is suggested, based on the sorption of Cd on AG 50W-X8 organic cation exchanger at 0.01M HNO3.109mAg is eluted with 0.2M NaCl, physiologically compatible for human use.

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Abstract  

Hydrated antimony pentoxide (HAP) as an absorbent for column operation has been prepared by hydrolysis of SbCl5 with deionized water. Sorption behavior of Sn, Cd, Sb and In was studied on HAP in HCl medium. Radiochemical separation of no-carrier added113mIn from113Sn/125Sb and115mIn from115Cd wa achieved over a HAPO column. The separated products were of high radionuclidic purity.

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Abstract  

Fission neutron spectrum averaged cross-sections were measured for the reactions64Zn(n, p)64Cu,67Zn(n, p)67Cu and68Zn(n, )65Ni by the activation technique, using radiochemical separations and -spectroscopy. The preparation of64Cu and67Cu in a nuclear reactor was studied. The64, 67Cu was separated from zinc matrix activity using anion exchange column technique.

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Summary  

The lyophilized MIBI kit was dissolved in 1 ml sterile saline or 250mg/ml ascorbic acid and dispensed into 0.2 ml fractions, which were stored at -20 °C for 12 days. The solution was prepared by using two different protection methods. In the first method evacuated vials were used for storage of fractionated solution while in the second method an antioxidant agent, ascorbic acid was employed. The radiochemical impurity of 99mTc-MIBI in the unprotected fractions rises with time. Exclusion of air as well addition of ascorbic acid in fractionated solutions gave very good results. The labeling efficiency and biodistribution of fractionated solutions was the same as the lyophilized kit even after 12 days.

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Abstract  

The adsorption behaviour of99Mo in the form of molybdate and of99mTc in the form of pertechnetate on hydrated titanium dioxide was investigated at different molarities of hydrochloric acid. The adsorption capacity of molybdate on hydrated TiO2 is higher than on Al2O3. A99mTc-generator is suggested. This generator is based on the adsorption of (99Mo) molybdate on hydrated TiO2, at acidities of 0.05–0.1M. HCl.99mTc is eluted with 0.9% NaCl. Radionuclidic, radiochemical and chemical purities of the eluates were checked. This generator seems to have a great potential as compared to the traditional alumina generators.

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Abstract  

The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ~99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.

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