A number of megatrends are hitting the world of work at the same time. These include the digital revolution, globalisation and rapid population ageing, which are all having a profound impact on the types of jobs that are being created and how and where they are performed. This paper examines the challenges confronting the Visegrad Group of countries and the broad policy responses that will be required. It looks at the risk of job automation, how the structure of employment is changing by skill level and the rise of the gig economy. These changes will require a combination of policy responses in the areas of employment regulation, measures to facilitate labour mobility and lifelong learning, social protection and social dialogue. In many cases, this will not require a complete paradigm shift in policies but an adaptation and strengthening of existing polices.