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Clinical and Experimental Medical Journal
Authors: Saleh Alqasoumi, Mohammed Al-Dosari, Mohammed Al-Sohaibani, Tawfeq Al-Howiriny, Mohammed Al-Yahya, and Syed Rafatullah

Abstract

Hibiscus sabdariffa L. (Roselle) is a vegetable known to possess various therapeutic properties. We evaluated the anti-ulcerogenic property of ethanolic extract of dried calyces (EEHS) in different ulcer models in Wistar albino rats. The extract at 250 and 500 mg/kg body weight, orally has a significant effect in cold restraint stress, pylorus ligation, necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl) and indomethacin-induced gastric ulcer models. The extract showed an ability to significantly protect against gastric mucosal injury in all models used. Furthermore, EEHS has significantly decreased the basal gastric acid secretion, as well as significantly increased gastric wall mucus secretion (GWM) and non-protein sulfhydryl (NP-SH) concentrations in gastric tissue. Whereas, the extract significantly reduced the ethanol-induced elevated levels of malondialdehyde (MDA) in the rat stomach. These pharmacological and biochemical findings were further supported by the histological assessment of the stomach. The phytochemical constituents present in the H. sabdariffa calyces may contribute to its anti-ulcer activity through one or more mechanism(s), including the antisecretory and antioxidant nature of the extract.

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