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Abstract  

In this study, we aim to evaluate the global scientific production of stem cell research for the past 16 years and provide insights into the characteristics of the stem cell research activities and identify patterns, tendencies, or regularities that may exist in the papers. Data are based on the online version of SCI, Web of Science from 1991 to 2006. Articles referring to stem cell were assessed by many aspects including exponential fitting the trend of publication outputs during 1991–2006, distribution of source title, author keyword, and keyword plus analysis. Based on the exponential fitting the yearly publicans of the last decade, it can also be calculated that, in 2,011, the number of scientific papers on the topic of stem-cell will be twice of the number of publications in 2006. Synthetically analyzing three kinds of keywords, it can be concluded that application of stem cell transplantation technology to human disease therapy, especially research related on “embryonic stem cell” and “mesenchymal stem cell” is the orientation of all the stem cell research in the 21st century. This new bibliometric method can help relevant researchers realize the panorama of global stem cell research, and establish the further research direction.

Restricted access
Acta Chromatographica
Authors:
Mei-Xia Zhu
,
Sheng-Nan Li
,
Hai-Dan You
,
Bin Han
,
Zhi-Ping Wang
,
Yan-Xi Hu
,
Jin Li
, and
Yu-Feng Liu

High-performance liquid chromatography coupled with photodiode array detection and evaporative light scattering detection (HPLC—DAD—ELSD) was established to determine paeoniflorin and albiflorin simultaneously in Radix Paeoniae Rubra. The assay was performed on a Diamonsil C18 (4.6 mm × 250 mm, 5 μm) column by a gradient elution program with acetonitrile and aqueous formic acid (0.05% v/v) as mobile phase at a flow rate of 1.0 mL min−1. The detection wavelength of DAD was 230 nm, and the evaporator tube temperature of ELSD was set at 110 °C with the nebulizing gas flow rate of 3 L min−1. The temperature of column was kept at 30 °C. The linear ranges of paeoniflorin and albiflorin were within 0.050–1.510 mg mL−1 and 1.007–5.035 mg mL−1. The recoveries of paeoniflorin and albiflorin were 96.2–102.9% and 95.0–102.4%, respectively, while the relative standard deviation (RSD) of them was 0.2–2.5%. This method was quick, simple, accurate, and specific. It could be used for the quality control of Radix Paeoniae Rubra. The proposed approach was expected as a powerful tool for the quality control of Radix Paeoniae Rubra.

Open access