Excess dietary intake may increase the risk for the hyperthyroidism in the elderly. This study investigated iodine dietary
intake by epithermal neutron activation analysis (ENAA) analyzing duplicate portion diet and fortified table salt samples.
Duplicate diet samples were obtained from a group of twenty-five steel mill workers from the city of São Paulo, over a 3-day
period. The samples were freeze dried, mixed and homogenized. Fortified table salt brands were collected from the market and
were analyzed with no pre-treatment. Assays for the iodine concentration in the table salt samples revealed values between
24 to 65 mg/kg. The average iodine daily intake for the worker’s diets was 813 μg/day, ranging from 402 to 1363 μg/day. In
some cases daily intakes were around 10 times higher than the recommended dietary allowance (RDA) value (150 μg/day).
Arsenic and cadmium contents in eight edible mushroom species (Agaricus bisporus, Agaricus sp, Pleurotus ostreatus, Pleorotus florida, Pleorotus eryngui, Pleurotus osteatus, Pleurotus salmoneostramineus,
Lentinula edodes) consumed by Brazilian population were determined by instrumental neutron activation analysis (INAA) and graphite furnace
atomic absorption spectrometry (GF AAS), respectively. Arsenic concentrations varied from 0.009 mg/kg in P. eryngui to 0.210 mg/kg dry weight in L. edodoes and Cd from 0.011 g/kg in P. eryngui to 0.229 mg/kg dw in P. salmoneostramineus. The consumption of mushrooms in São Paulo-Brazil may be considered safe from a toxicological point of view as As and Cd
presented levels of ingestion are below the maximum levels recommended by the World Health Organization.
Worldwide Brazil is among one of the 22 countries with high rates of tuberculosis placing this disease as a priority for the Government Health Policies in this country. Studies with the main tuberculostatic drugs rifampicin, isoniazid, pyrazinamide, and ethambutol, aiming the development of fixed-dose combination formulations (FDCs) have been performed. The aim of this study was to evaluate the thermal behavior of these drugs by DSC, TG/DTG, and DTA in order to predict possible physical and chemical interactions between tuberculostatics. DSC and DTA curves suggested incompatibility and/or interactions among drug preparations resulting from new thermal events, as well as the disappearance and shift of the melting point of the drugs. TG/DTG curves of drug mixtures presented different profiles from those observed for the individually tested drugs, supporting the evidence of drug incompatibility and indicating that mixtures are less stable when compared to the drugs alone.