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The complex formation of the bifunctional monophosphinic acid DOTA analogue DO3APABn (1,4,7,10-tetraazacyclododecane-4,7,10-triacetic-1-{methyl[(4-aminophenyl)methyl] phosphinic acid}) with 111In at a tracer level was analyzed. Formation of a complex between 111In and DO3APABn was very rapid even at room temperature and high radiolabeling yields were achieved. As introducing the methylphosphinic acid arm to the DOTA structure generated a chiral centre, more than one peak (probably corresponding to various diastereoisomers) of 111In-DO3APABn were separated on HPLC. Four peaks were separated by HPLC, they probably correspond to four diastereoisomers of 111In-DO3APABn originating from combination of chirality of complexes of DOTA-like ligands with chirality of coordinated phosphorus atom. Studies in rats showed rapid elimination of radioactivity from the blood and other organs and tissues. The results indicate that DO3APABn represents a promising ligand for radiolabeling of target-specific biomolecules with radiometals.

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Authors: P. Soudek, E. Podracká, M. Vágner, T. Vanìk, P. Petřík and R. Tykva
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Authors: I. Tamáska, Z. Vértesy, A. Deák, P. Petrik, K. Kertész and László Biró

Bioinspired 1+2D nanoarchitectures inspired by the quasi-ordered structures occurring in photonic nano-architectures of biological origin, like for example butterfly scales, were produced by depositing a layer of SiO2 nanospheres (156 nm and 292 nm in diameter) on Si wafers, over which a regular multilayer composed from three alternating layers of SiO2 and TiO2 was deposited by physical vapor deposition. Flat multilayers were deposited in the same run on oxidized Si (324 nm SiO2 thickness) for comparison. Different types of disorder (in plane and out of plane) were purposefully allowed in the 1+2D nanoarchitectures. The positions of the specular reflection maxima for the flat multilayer and for the two different bioinspired nanoarchitectures were found to be similar. Additionally to this, the bioinspired nanoarchitectures exhibited angle independent diffuse reflection too, which was absent in the flat multilayer. Different model calculations were made to explain the specular and diffuse optical properties of the samples. Satisfactory agreement was obtained between experimental data and model calculations.

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