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  • Author or Editor: Petr Kastner x
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Reversed-phase (RP) TLC retention behavior has been examined for two series of potential antituberculotic drugs. Effects of the type and proportion of the organic component of the mobile phase were tested, because these can affect retention. Experimentally measured lipophilicity values and values calculated by means of a computational method were compared to determine the extent of any correlation. It was found that substitution of the aromatic ring, in particular with chlorofluoro or more complicated substituents, negatively affected the correlation between measured and calculated values.

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RPTLC retention characteristics have been examined for two series of potential antituberculotic drugs. Various effects were tested which can be manifested in the values of properties measured — i.e. the effect of the type and proportion of the organic component of the mobile phase, and the effect of the pH of the aqueous component of the mobile phase. Experimentally obtained measures of lipophilicity were correlated with each other and with values calculated by a computational method. In this study some substituents, in particular nitro groups or more complicated substitution of the aromatic ring, negatively affected the correlation of the measured values with those calculated.

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RPTLC retention characteristics have been examined for a series of potential antituberculotic drugs derived from 2-benzylsulfanylbenzothiazole. The effects of the type and proportion of the organic component of the mobile phase were investigated. Experimentally obtained measures of lipophilicity were correlated with each other and with values calculated by a computational method. Some substituents, e.g. nitro and chlorofluoro groups, or more complicated substitution of the aromatic ring, negatively affected correlation of measured values with those calculated.

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