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Journal of Flow Chemistry
Authors: Jill E. Hochlowski, Philip A. Searle, Noah P. Tu, Jeffrey Y. Pan, Stephen G. Spanton and Stevan W. Djuric

Abstract

We report herein a high-throughput integrated ynthesis–purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmented-flow synthesizer was integrated to a preparative HPLC-MS, where each reaction product was purified immediately upon reaction completion. Further, automated structure-validation processes accelerate the rate at which drug discovery candidates are available for biological screening.

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