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European Journal of Microbiology and Immunology
Authors:
Prabhu Nesargikar
,
B. Spiller
, and
R. Chavez
Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.
