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- Author or Editor: R. Durak x
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Abstract
Two analytical shape functions representing the shapes of 
- and characteristic X-ray photopeak sides obtained with a Ge(Li) detector are described. The photopeak centroid is accurately determined by using these functions. Energy dependence of photopeak tailing at the lower energy side of the photopeaks are obtained by the least-squares fitting method. The present method can be used for the analysis of partly overlapped photopeaks, one side of which is well resolved, with a sufficient accuracy.
Abstract
Magnetically targeted drug delivery by particulate carriers is an efficient method of delivering drugs to localized disease sites, such as tumors. Thus, high concentrations of carrier molecules such as therapeutic radiopharmaceuticals can be achieved near the target site without any toxic effects to normal surrounding tissue. In this study, magnetic targeting carriers (MTC) were radioiodinated with 131I using three different methods (1) 131I was directly bound onto MTC, (2) an iron complex of 8-hydroxyquinoline (8-OHQ) has been absorbed onto magnetic microspheres. The iodogen method was performed for the iodination of the complexes. (3) 8-OHQ was radioiodinated before chelating with Fe. Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The best labeling yield and the best stability were obtained when 8-OHQ was chelated before the radioiodination. Binding efficiency was found to be 99.58%. The labeling of the MTC with 131I was undertaken to allow for therapy with 131I-labeled MTC with simultaneous imaging.
