Authors:Laura Carroccia, Biagia Musio, Leonardo Degennaro, Giuseppe Romanazzi and Renzo Luisi
Microreactor-mediated organocatalysed Michael reactions have been developed. By using a soluble proline-derived catalyst, Michael-type reactions, leading to γ-nitroketones, have been optimized in homogeneous and continuous-flow conditions. As proof of principle, an integrated microfluidic system able to perform domino processes useful in the preparation of bicyclo[4.4.0]decanes with six contiguous stereogenic centres has been set up.
Authors:Leonardo Degennaro, Claudia Carlucci, Sonia De Angelis and Renzo Luisi
In this review recent examples on the use of flow technology for organometallic-mediated synthesis have been collected. The review focused on synthetic relevant processes and on flow techniques developed for handling reactive intermediates, and conduct synthetic steps difficult to perform using traditional "batch" chemistry.