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  • Author or Editor: Rozana Nazaryan x
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Background and aims

Prevalence of atopic diseases is progressively increasing in children with unclear clinical picture in oral cavity. This study aimed to find correlation between the total antioxidant and periodontal status in the saliva of periodontally compromised with atopy.

Materials and methods

The groups consisted of patients of atopic diseases and gingivitis (ADG), of atopic diseases without gingivitis (AD), and healthy controls (HC). The level of gingival inflammation was evaluated using the sulcus bleeding index (SBI) reported by Mühlemann and Son. Glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) were estimated in saliva.

Results

The mean salivary MDA levels of group HC was significantly lower compared with group ADG and AD (P < 0.05). Similarly, in the case of salivary GSH, marker levels revealed a significant decrease (P < 0.05) when mean values in the control group (5.12 ± 0.66 µmol/L) were compared with the ADG (2.31 ± 0.44 µmol/L) and AD groups (2.69 ± 0.56 µmol/L). The SOD activity was significantly lower in the ADG and AD groups compared with HC.

Discussion

As there was no significant difference in the level of SOD concentration between groups, we suggest that antioxidant imbalance is primarily explained by atopic disease.

Conclusion

The results showed changes in antioxidant balance in children with atopy.

Open access