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  • Author or Editor: S. Cohn x
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Abstract  

High energy gamma-radiation (8 to 30 MeV) is gaining acceptance for radiation therapy of patients with deep cancers. This radiation is of sufficient energy to induce photonuclear activation of the elements in the human body. Our results of measurements of nitrogen and phosphorus in an anthropomorphic phantom, a cadaver, and a cancer patient with bremsstrahlung radiation from 15 MeV electrons demonstrate the feasibility of a method to monitor these two elements in the human body in vivo by measuring the radioactivity induced in these targets by photonuclear reactions.

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Abstract  

Total body neutron activation analysis (TBNAA) has used to determine the absolute levels of total body sodium (TBNa) and total body chlorine (TBCl) in 81 normal adults. For the age span studied (30–90 years), the mean values of TBNa and TBCl remained relatively constant for males, but decreased slightly for females beyond sixty years of age. In order to reduce the variability in this cross-sectional study, the TBNa and TBCl values were normalized for body dimensions (weight, height, body surface area) as well as age and sex. In addition, TBNa was related to skeletal mass (total body calcium) and lean body mass (total body potassium). The quantity of body sodium in excess of the chlorine space was determined. This value, defined as sodium excess, was significantly correlated with total body calcium. The values for total body sodium, total body chlorine, and sodium excess obtained in the present study were compared with values previously reported in the literature.

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