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  • Author or Editor: S. Somasundaram x
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Abstract  

129I content of batches of Na131I vials, used for nuclear medicine procedures, was estimated by neutron activation analysis. The average value of the129I/131I activity ratio /corresponding to zero decay time of the latter/ was /4.98±2.8/x10–9. It is concluded that the contribution of129I from medical applications of131I in India is insignificant in relation to that from nuclear fuel cycle activities.

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Abstract  

Methods have been developed for the routine analysis of129I in effluents of fuel reprocessing plants using 29.4 keV xenon X-rays. Direct counting methods have been standardized in liquid medium as well as in ion-exchange resin medium. A low energy photon spectrometry Ge detector system and a well-type NaI/Tl/ detector are used for direct counting. Attenuation of xenon X-rays in liquid medium as well as in ion-exchange resin medium have been studied. Sample size is optimized by studying the self attenuation of xenon X-rays in the sample. Activity as low as 1 Bq could be detected with an accuracy of 11% and 30% using LEPS and NaI/Tl/counting systems, respectively.

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Abstract  

A simple separation scheme for the analysis of As, Mn, Mo, Cu and Zn using neutron activation is described. It has been checked using three standard reference materials, A-11 milk powder (IAEA) and bovine liver and orchard leaves (USNBS) and found to give acceptable results. This scheme was applied for determination of these trace elements in mature human milk samples. The concentrations of As, Mn, Mo, Cu in samples obtained from two socio-economic groups—low and middle incomes—were not significantly different. However, Zn levels in samples obtained from the poor income group were significantly lower than in those obtained from the other group.

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Journal of Radioanalytical and Nuclear Chemistry
Authors: H. Dang, H. Desai, S. Kayasth, D. Jaiswal, C. Wadhwani, and S. Somasundaram

Abstract  

The daily intakes of trace elements by infants showing optimal pattern of growth are used as the basis to estimate the requirements of Fe, Co and Se during infancy. Since milk is the only food and source of nutrition in the first few months of life, the requirements of these elements are calculated from their average concentrations in human milk and the volume of milk required to supply sufficient amount of energy for maintenance and healthy growth of infants. The concentrations of the three elements in human milk were determined, using the technique of neutron activation followed by radiochemical separation.

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European Journal of Microbiology and Immunology
Authors: Markus M. Heimesaat, K. Heilmann, A. A. Kühl, U. Erben, M. Rühl, A. Fischer, R. W. Farndale, S. Bereswill, U. B. Göbel, M. Zeitz, R. Somasundaram, and C. Freise

Abstract

In experimental models of and humans with intestinal inflammation, increased levels of the matrix-degrading gelatinases MMP-2 and -9 in inflamed tissues can be detected. The synthetic collagen analogue (Gly-Pro-Hyp)10, (GPO)10, has been identified as a relevant binding structure for proMMP-2/-9 and promotes enzymatic activity of proMMP-2. Since targeted MMP strategies might offer promising anti-inflammatory treatment options, we for the first time studied in vivo actions exerted by (GPO)10 applying an acute dextrane sulfate sodium (DSS) induced colitis model. Seven-day intraperitoneal (GPO)10 treatment ameliorated clinical symptoms and histopathological colonic changes as compared to placebo controls with severe colitis. (GPO)10-treated mice displayed a diminished influx of neutrophils, and T- and B-lymphocytes into their colonic mucosa whereas numbers of regulatory T-cells and regenerative cells were higher as compared to placebo controls. Furthermore, IL-6 secretion was down-regulated in ex vivo colonic biopsies derived from (GPO)10-treated mice whereas higher concentrations of the anti-inflammatory cytokine IL-10 in extra-intestinal compartments such as MLN and spleen could be detected. Strikingly, influx of inflammatory cells into lungs was abolished following (GPO)10 application. We therefore propose (GPO)10 as a promising effective and safe treatment option of intestinal and extra-intestinal inflammatory conditions in humans.

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