Search Results

You are looking at 1 - 1 of 1 items for

  • Author or Editor: Selvadurai Muralidharan x
  • All content x
Clear All Modify Search
JPC - Journal of Planar Chromatography - Modern TLC
Authors: Selvadurai Muralidharan, Subramania Meyyanathan, Nithyanantham Muruganantham, Sekar Rajan, Kaliaperumal Krishnaraj, and Bhojraj Suresh

A simple, sensitive, precise, and rapid high-performance thin-layer chromatographic (HPTLC) method for analysis of dexibuprofen in pharmaceutical formulation has been developed and validated. The method uses aluminum foil HPTLC plates coated with silica gel 60F 254 as stationary phase and hexane-ethyl acetate-glacial acetic acid 7.5:2.5:0.5 ( v/v ) as mobile phase. Densitometric analysis of dexibuprofen and the internal standard (aceclofenac) was performed in reflectance mode at 217 nm. The system was found to give compact bands for dexibuprofen ( R F 0.50). Linear regression analysis of the calibration data revealed a good linear relationship between response and concentration in the range 50–300 ng per band ( r 2 = 0.9902). The method was validated for precision, accuracy, recovery, and robustness. The method has been successfully applied to analysis of an oral solid dosage formulation.

Restricted access