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  • Author or Editor: Sh. Luo x
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Abstract  

Structure activity relationship (SAR) has been playing a more and more important role in medicine design. We presented here a preliminary investigation on the relationship between the structure of different phosphonates and the preparation of corresponding complexes labeled with 153Sm. By study of seven complexes, it was found that the number of -PO3H2 groups, the stereoscopic distance between them and the existence of strong electron-providing groups in the ligand molecule affected the preparation of 153Sm-complex.

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Abstract  

Samarium-153-EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for boné cancer in human beings. In this article, we present the results on synthesis and structure analysis of Samarium-153-EDTMP. In a basic medium,153Sm-EDTMP can be readily prepared with a complexing yield not less than 98%, and it is confirmed that the ratio of the ligand to Sm is 11, and the charge of153Sm-EDTMP is negative two.

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