Authors:Jin-Hwan Kim, Sun-Ju Choi, and Young-Don Hong
The organometallic precursor of fac-[99mTc(CO)3(H2O)3]+ has attracted much attention because of the robustness and small size of Tc(I)-tricarbonyl complexes compared to Tc(V) complexes
and the good labeling affinity with a variety of donor atoms. Among various ligand systems, an iminodiacetic acid (IDA) was
proven as a good chelating group to form a Tc(III)-compelx as well as has been shown its potential as a chelating system for
fac-[99mTc(CO)3] precursor. In an attempt to confirm the similarity and the difference between 99mTc(CO)3-IDA and 99mTc-(IDA)2-complex, M(CO)3-IDA (M = 99mTc, Re) complexes of disofenin, mebrofenin and N-(3-iodo-2,4,6-trimethyl phenylcarbamoylmethyl) iminodiacetic acid were prepared, and the biological evaluation of 99mTc(CO)3-disofenin was performed. The 99mTc(CO)3-IDA complexes were prepared with a high radiolabeling yield (>98%) in a quantitative manner and showed a negative charge.
The in vivo pharmacokinetic behavior of 99mTc(CO)3-disofenin showed a similar biological activity to 99mTc-(disofenin)2 in that those complexes were quickly cleared from the blood by the hepatocytes and excreted into the gallbladder and intestine.
Accordingly, the 99mTc(CO)3-IDA derivatives of disofenin and mebrofenin might be used as hepatobiliary imaging agents. Since an IDA is a promising chelator
for 99mTc-based radiopharmaceutical and the biological properties of 99mTc(CO)3-IDA derivative shows similar to that of 99mTc-complex, a biomolecule containing IDA can be freely radiolabeled with fac-[99mTc(CO)3]-precursor or 99mTc. However, the radiolabeling efficiency and the biological behavior demonstrates the favorable properties of 99mTc(CO)3-IDA compound for the development of a new imaging agent.
Authors:Yong Chung, Sun Kim, Gwang Sun, Jong Lim, Jong Moon, Kye Lee, Young Kim, Jong Choi, and Ju Lee
The analysis of mineral contents in space foods is needed to obtain an information on a comprehensive elemental composition
as well as the investigation on the effects of human nutrition and health based on the dietary intake of mineral elements.
Recently, six items of new Korean space foods (KSFs) such as kimchi, bibimbap, bulgogi, a ramen, a mulberry beverage and a
fruit punch which was developed by the KAERI, and the contents of more than 15 elements in the samples were examined by using
instrumental neutron activation analysis (INAA). Five biological certified reference materials, NIST SRM were used for analytical
quality control. The results were compared with those of common Korean foods reported, and these results will be applied toward
the identification of irradiated foods.