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Male Wistar rats wearing chronically implanted cortical electrodes were exposed to Mn-containing nanoparticles via the airways for 8 weeks following a 2-week pre-exposure period. The rats’ cortical electrical activity and open field motility was recorded simultaneously, in weekly repetitions. It was supposed that this technique can provide better insight in the development of Mn-induced CNS damage. Decreased motility (less distance covered, longer periods of immobility) and increased total power of cortical electrical activity developed in parallel in the first 4–5 weeks of treatment but showed little change afterwards. Both the behavioral and the electrophysiological effect were in fair correlation with the rats’ internal Mn exposure determined from brain samples. The results confirmed the non-linear dose- and time-dependence of Mn effects suggested by previous studies. Repeated simultaneous behavioral and electrophysiological recording during a longer treatment with neurotoxic metals (or other xenobiotics) seems to be a promising method.

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Magyar Sebészet
Authors: Zsolt Szentkereszty, János Pósán, Katalin Pető, Péter Sápy, Miklós Boros, István Takács, and Sándor Sz. Kiss

Absztrakt

Bevezetés: A sternoclavicularis ízület pyogen fertőzése ritka kórkép, melynek kezelése lehet konzervatív (antibiotikumok), vagy sebészi (az ízület feltárása és drainage-a, illetve annak resectioja). A szerzők elemzik a sternoclavicularis ízület pyogen fertőzése miatt kezelt betegek oki és predisponáló tényezőit, tüneteit, a diagnózis és a műtéti kezelés kérdéseit és annak eredményességét.

Betegek és módszer: A 6 betegnél (5 férfi, egy nő, átlagéletkor: 56, 8 év) a kiváltó ok 2-2 esetben trauma, illetve távoli szeptikus góc, 1-1 esetben intraarticularisan adott injekció, illetve korábbi sugárkezelés volt. A betegségre hajlamosító tényező (diabetes mellitus, köszvény, krónikus alkoholizmus és májcirrho-sis) 2 betegnél volt kimutatható. A leggyakoribb tünet az ízület duzzanata, a bőrpír, a láz, a fájdalom és a váll mozgáskorlátozottsága volt. Valamennyi betegnél a CT-vizsgálat igazolta az ízület destructioját. Konzervatív terápiát egy esetben alkalmaztak, de ennek eredménytelensége miatt radikális resectiot végeztek. Egy-egy betegnél a többszörös szeptikus góc és a kísérő mediastinitis miatt először debridement és drainage műtét, később második ülésben resectio, a többi három betegnél első ülésben az ízület resectioja történt.

Erdemények: A konzervatív, illetve drainage kezelés mindhárom esetben eredménytelen volt, ezzel szemben az ízület resectioja valamennyi betegnél gyógyulást eredményezett. Műtéti szövődményt nem észleltek. Radikális műtét után átlagosan 28,2 hónappal a funkcionális eredmények kiválóak voltak.

Következtetések: A konzervatív kezelés és a drainage csak akkor ajánlott, ha súlyos szövődmények társulnak a betegséghez. Ilyenkor második ülésben érdemes resectiot végezni. A legeredményesebb kezelési módnak a radikális resectiot tartják.

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Magyar Sebészet
Authors: Lukács Veres, Sándor Sz. Kiss, Regina Kiss, Attila Enyedi, Tamás Végh, László Damjanovich, and István Takács

Absztrakt

A spontán nyelőcsőruptura kezelése magas morbiditással és mortalitással jár. Primer sebészeti ellátást követően számos szövődménnyel szembesülhetünk. Egy 29 éves Boerhaave-syndromás férfi beteg esetében a suturázott nyelőcsőszakasz insufficientiáját a stentelés sem oldotta meg, ezért transgastricus drainage-t alkalmaztunk. Ezzel lassan, fokozatosan letapadt a sérült terület, a beteg nem szorult újabb műtétre, nyelőcsövét meg lehetett őrizni. Strictura sem alakult ki. A transgastricus nyelőcsődrainage válogatott esetekben eredményes kezelési eszköz lehet.

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Interventional Medicine and Applied Science
Authors: K. Shanava, Sz. Horváth, F. Karl-Hermann, Sz. Jávor, I. Takács, B. Balatonyi, S. Ferencz, A. Ferencz, E. Rőth, and György Wéber

Abstract

Introduction:The Natural Orifice Transluminal Endoscopic Surgery (NOTES) is an abdominal operation carried out with flexible endoscopic instruments and their advanced versions via natural orifices. The NOTES causes theoretically less pain, operative stress, shorter hospitalization, quicker recovery and it is scarless. The aim of this investigation was to evaluate the feasibility and safety of transgastric small bowel resection. Materials and methods: Seven domestic pigs were investigated and entered the study; body weight 25 kg in average. General anesthesia was performed. One trocar was used for laparoscopic observations during gastrotomy and transgastric penetration with the gastroscope, later for assistance with a grasper for manipulation of the bowel loops and for the application of the linear stapling device. Then the needle knife was used to complete a 1.5 cm long incision in the gastric wall. The gastroscope was advanced into the peritoneal cavity and a small bowel loop was identified and elevated with a flexible grasper. Through the second channel of the scope a coag grasper was used to dissect the mesentery. Then a linear stapler was inserted through the assisting trocar and the resection was performed. Afterwards the bowel ends were opened with the needle knife and the stapler was reinserted for a side-to-side anastomosis. The specimen was removed via the stomach. Gastric closure was completed by laparoscopic mini-instruments through the stapler-port. All special events and all problems were prospectively documented. Follow-up was performed over 2 weeks and body weight was recorded. Then a laparoscopy was performed to document adhesions or abscess formation. Finally the animals were sacrificed to evaluate further evidence of infection or adhesions. Results: The operations were carried without complications, there was no case of letal outcome. On the 12th day the abdominal laparoscopic revision was carried out, after the revision in one case adhesion could be detected, no other kinds of complications were noticed. Conclusion: According to our results, the transgastric small bowel resection is a safe procedure, but further special instruments are needed. These experimental procedures should be evaluated carefully and critically in clinical practice.

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Interventional Medicine and Applied Science
Authors: H. Vágó, P. Takács, A. Tóth, L. Gellér, Sz. Szilágyi, L. Molnár, V. Kutyifa, T. Simor, and Béla Merkely

Abstract

Cardiac electromechanical resynchronisation therapy (CRT) is an effective non-pharmacological treatment of patients suffering from drug refractory heart failure. However, approximately 20–30% of patients are non-responder. Cardiac magnetic resonance imaging (CMR) may play significant role in clarifying many questions in this patient population. Forty-five patients, suffering from severe drug refractory heart failure, underwent CMR before applying CRT. Left ventricular end-diastolic, end-systolic volumes, ejection fraction, myocardial mass, wall motion disturbances, localisation of non-viable myocardium were determined. Left ventricular dyssynchrony was determined by illustrating wall-time thickening in short-axis slices of left ventricle from basis to apex. CMR-proved underlying heart disease were postinfarction heart failure, dilated cardiomyopathy and non-compaction cardiomyopathy in 62, 27 and in 11%, respectively. Mean left ventricular ejection fraction was 24.5±10%, intraventricular dyssynchrony was 200±78 ms. In four patients, requiring surgical revascularisation after unsuccessful coronary sinus electrode implantation, optimal position for epicardial screw-in electrode was selected. According to the results of CMR, biventricular device was not implanted in 7 patients. During the follow-up of the 38 patients, 5 patients (13.16%) were non-responders, despite the approximately 22% non-responder ratio in our whole patient population treated by CRT but without performing previous CMR examination. In this patient population CMR may have a significant role in the selection of responder patient population.

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Magyar Sebészet
Authors: Lukács Veres, Regina Kiss, Miklós Boros, Attila Enyedi, István Takács, Sándor Kollár, László Damjanovich, and Sándor Sz. Kiss

Absztrakt

A baleseti és ortopéd sebészek gyakran használnak tűződrótot a clavicula és a humerus rögzítésére. A fémanyagok mellüregbe történő elvándorlása ritkán fordul elő. Egy idős nőbeteg humeroscapularis ízületét ismételt jobb vállficama miatt 6 héttel korábban Kirschner-drótokkal tűzték meg. Kontrollröntgen során fedezték fel, hogy a tűződrótok a jobb mellüregbe vándoroltak. Videothoracoscopos úton technikailag nem lehetett őket eltávolítani, ezért jobb oldali thoracotomia történt. Pneumolysist követően a 2-es tüdősegmentumból és a kupolánál, medialisan a gerinccsatornába fúródó Kirschner-drótot távolítottak el. A posztoperatív időszakban sebészeti komplikáció nem volt. A szerzők áttekintik ennek a ritkán előforduló szövődménynek az irodalmát és felhívják a figyelmet, hogy a mellüregbe vándorolt tűződrótok eltávolítása szükséges a fenyegető súlyos szövődmények megelőzésére.

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Interventional Medicine and Applied Science
Authors: Szaniszló Z. Jávor, K. Shanava, E. Hocsák, M. Kürthy, J. Lantos, B. Borsiczky, I. Takács, Sz. Horváth, B. Balatonyi, S. Ferencz, A. Ferencz, E. Rőth, and Gy. Wéber

Abstract

Increased intra-abdominal pressure during laparoscopy leads to hypoxia due to reduced blood flow. Aim of our study was to investigate whether preconditioning can reduce this negative effect of the pneumoperitoneum. Fifty female Wistar rats were used, divided into 5 groups. I: Sham operation (Sham), II: conventional pneumoperitoneum (PP), III: transvaginal pneumoperitoneum (TV), IV: preconditioning for 2.5 minutes in two cycles (Pre 2.5), V: preconditioning for 5 minutes (Pre 5). Malondialdehyde (MDA), reduced glutathione (GSH), sulfhydrylgroup (SH-) concentrations, superoxide-dismutase (SOD) and mieloperoxidase (MPO) activity, and anti-apoptotic pathway marker p-AKT level and inflammatory cytokine TNF-α were measured. SOD activity and GSH concentration were decreased in PP and TV groups comparing to Sham and preconditioning groups. MPO activity was decreased also in PP and TV groups comparing to the Sham group but in the preconditioning groups it has remained high. MDA concentration in plasma was increased in PP and TV groups comparing to Sham and preconditioning groups. There was no difference in the case of blood MDA and SH-concentrations between groups. Anti-apoptotic pathway marker p-AKT level was decreased in the TV group comparing to the sham and preconditioning groups. TNF-α level was increased in TV and preconditioning groups compared to the sham group. According to the results preconditioning can reduce negative effects of pneumoperitoneum.

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Acta Botanica Hungarica
Authors: P. Török, E. Tóth, K. Tóth, O. Valkó, B. Deák, B. Kelbert, P. Bálint, Sz. Radócz, A. Kelemen, J. Sonkoly, T. Miglécz, G. Matus, A. Takács, V. A. Molnár, K. Süveges, L. Papp, L. Papp Jr., Z. Tóth, B. Baktay, G. Málnási Csizmadia, I. Oláh, E. Peti, J. Schellenberger, O. Szalkovszki, R. Kiss, and B. TÓthmérész

For understanding local and regional seed dispersal and plant establishment processes and for considering the ecotypes and other forms of specific variability, hard data of locally or regionally measured traits are necessary. We provided newly measured seed weight data of 193 taxa, out of which 24 taxa had not been represented in the SID, LEDA or BiolFlor databases. Our new measurements and formerly published data of locally collected seed weight records together covers over 70% of the Pannonian flora. However, there is still a considerable lack in seed weight data of taxonomically problematic genera, even though they are represented in the Pannonian flora with a relatively high number of species and/or subspecies (e.g. Sorbus, Rosa, Rubus, Crataegus and Hieracium). Our regional database contains very sporadic data on aquatic plants (including also numerous invasive species reported from Hungary and neighbouring countries) and some rare weeds distributed in the southwestern part of the country. These facts indicate the necessity of further seed collection and measurements.

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