T-cell large granular lymphocytic leukemia is a rare, heterogeneous, mature T-cell neoplasia, often complicated with autoimmune disorders.
The old man was diagnosed with T-cell large granular lymphocytic leukemia due to lymphocytosis and neutropenia. The patient suffered from a couple of autoimmune diseases such as gluten sensitivity, primary biliary cirrhosis, and pure red cell aplasia. The severe pure red cell aplasia proved to be resistant to the standard immunosuppressive drugs, but alemtuzumab therapy induced complete remission.
We explain the pathogenesis of the immune dysregulation and recapitulate the treatment options for a refractory disease.
The objective of this experiment was to determine whether fumonisin B1 (FB1) added to the diet of rats in a dose of 50 mg/kg changes the production of heat shock protein 70 (Hsp70) in the lungs and kidney of rats. We also studied the effect of this mycotoxin on the antioxidant system of the body. Mature (8 weeks old) male Wistar Crl:WI BR rats (n = 6/group) were fed the toxin-containing diet for 5 days. FB1 resulted in a 7% body weight reduction without significantly changing the feed intake. Western blot analysis of the lungs and kidney demonstrated a substantial (1.4-fold and 1.8-fold, respectively) increase in Hsp70 expression. Alterations could not be detected in the clinical chemical parameters (total protein, albumin, total cholesterol, glucose, creatinine and urea concentrations, and aspartate aminotransferase activity). There was no statistically significant change in malondialdehyde concentrations and the measured antioxidant parameters (the amount of reduced glutathione, GSH and glutathione peroxidase activity, GPx) in the blood plasma, lung and kidney tissue. Thus, it can be concluded that FB1 did not induce oxidative stress in the lungs and kidney, but increased Hsp70 production.