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Sámuel Domby of Gálfalva (1729–1807) defended his doctoral dissertation De vino Tokaiensi at the University of Utrecht in 1758, and it was published in the same year. Domby was not the first medical student to write about the curative effects of the Tokaj-Hegyalja wines, but his book is really considered unique because he summarised and in many ways also exceeded the knowledge of earlier authors on the subject. He not only communicated what was known about the wines of Tokaj-Hegyalja, but also demonstrated through a series of medical, meteorological observations and chemical experiments why these wines were so excellent, what effects they had on a healthy human body and what ailments could be effectively treated by drinking them. In many respects, his work has stood the test of time: for instance his observations on the importance of terroir and the protection of origin are still worth considering today.

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