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  • Author or Editor: T. Gomes do Nascimento x
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Abstract  

This study demonstrates the thermalanalysis applications in compatibility and stability studies of the propranolol binary mixture sand tablets A and B. The propranolol binary mixtures were prepared in the laboratory and compared to the fully formulated tablets using the thermogravimetric (TG) and calorimetric(DSC) methods. DSC of binary mixtures showed similar phase transition to propranolol drug. The tablets phase transition decreased and there was no detectable significant interaction in propranolol–lactose mixture and tablets. The DSC-photovisual test revealed an interaction similar to the Maillard reaction. The TG isothermal study showed a difference in the profile between the drug and tablets due excipients quality and problems in manufacture process. The kinetic parameters indicated a lower stability for the tablets than propranolol drug. The thermal techniques thermally differentiated the propranolol preparations demonstrating the importance in the design development of pharmaceuticals solid-dosage form.

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Abstract  

The present work reports studies of the thermal behaviour of some anti-hypertensive drugs. Their purities were determined by DSC and specialized pharmacopeial methods. The activation energy values suggest the following sequence of satability: nifedipine>propanolol hydrochloride>captoril. Analysis of the DSC data indicated that the degrees of purity of nifedipine, captopril and propanolol hydrochloride were similar to those found by pharmacopeial methods BP 93 and USP 23. The simplicity, speed and low operational costs of thermal analysis justify its application in the quality control of pharmaceutical drugs.

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