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- Author or Editor: Tahira Shehzadi x
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Abstract
Adenosine triphosphate (ATP) is an energy compound present in living organisms and is required by living cells for performing operations such as replication, molecules transportation, chemical synthesis, etc. ATP connects with living cells through specialized sites called ATP-sites. ATP-sites are present in various proteins of a living cell. The life span of a cell can be controlled by controlling ATP compounds and without the provision of energy to ATP compounds, cells cannot survive. Countless diseases treatment (such as cancer, diabetes) can be possible once protein active sites are predicted. Considering the need for an algorithm that predicts ATP-sites with higher accuracy and effectiveness, this research work predicts protein ATP sites in a very novel way. Till now Position-specific scoring matrix (PSSM) along with many physicochemical properties have been used as features with deep neural networks in order to create a model that predicts the ATP-sites. To overcome this problem of complex computation, this exertion proposes k-mer feature vectors with simple machine learning (ML) models to attain the same or even better performance with less computation required. Using 2-mer as feature vectors, this research work trained and tested five different models including KNN, Conv1D, XGBoost, SVM and Random Forest. SVM gave the best performance on k-mer features. The accuracy of the created model is 96%, MCC 90% and ROC-AUC is 99%, which are the same or even better in some aspects than the state-of-the-art results. The state-of-the-art results have an accuracy of 97%, MCC 78% and ROC-AUC is 92%. One of the benefits of the created model is that it is much simpler and more accurate.
Abstract
With the escalating density of vehicles converging at road intersections, the surge in road accidents, traffic conflicts, and traffic congestion has emerged as a pressing concern. This research paper addresses these challenges by employing MC (manual control) techniques to mitigate encroachment issues at three selected intersections. These intersections were identified through a comprehensive analysis of the Ranking-based Instance Selection (RIS), enabling the design of suitable measures to facilitate smooth traffic flow and minimize the occurrence of crashes. In order to gather pertinent data, the study incorporates various parameters such as traffic volume, peak flow rate (PFR), traffic conflicts, accidents, and intersection inventory. Through the implementation of our proposed approaches, which involve both MC techniques and signalized operation, a supreme level of service (LOS) is attainable. Notably, our findings demonstrate a remarkable reduction in the volume-to-capacity ratio (v/c ratio) of up to 0.62. This paper thus serves as a significant contribution to the field of traffic management, offering practical insights for optimizing intersection design and effectively addressing the challenges posed by increased traffic density.
