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Thermal analysis methods and X-ray diffractometry provided data on and permitted practical use of the eutectic mixture between Na2O·2SiO2 and SiO2, which melts at 790°C. Based on this, water glass was used as a binder to obtain artificial cluster granules, ceramically hardened by heating at 800°C. The process of water glass hardening in the presence of hardening reagents such as Na2SiF6, NH4Cl, silica gel and ultra-fine silica was studied by thermal analysis. In the first stage, gelification of the SiO2 sol takes place by neutralization of the NaOH deflocculant, while the second stage involves tridimensional cross-linking by polycondensation, promoted by powders rich in SiO2.
Thermal analysis up to 1550 °C on natural and synthetic materials containing CaSO4 revealed the temperature ranges of dehydration, impurity content decomposition and CaSO4 decomposition. CaSO4 decomposition starts above 1200 °C and proceeds in several steps, depending on the CaO content. CaSO4 forms several eutectic compositions with CaO (at 1340, 1390, 1410 and 1450 °C), each decomposition step being preceded by the formation and fusion of a eutectic composition, the decomposition taking place in the melt.
Abstract
The aim of this study was to evaluate the effect of methyl donor biovectors as cocktail formulation in cancer therapy. Based on our previous results regarding the pharmacokinetic of [Methyl-14C] Choline and [Methyl-3H] S-Adenosyl-Methionine (SAM) in presence of Folic Acid and their properties in the regulation of transmethylation metabolism, a cocktail solution of SAM, Choline and Folic Acid was prepared taking into account the previosly established molar ratios. The studies regarding the therapeutic effect of cocktail solution were effectuated on RS1 tumor bearing animal models. For evaluation of tumour cell proliferation we used the [Methyl-3H]-Thymidine with 25 Ci/mmol specific activity. The biodistribution studies were perfomed on untreated and treated tumuor bearing animals. The animal lots dedicated for treatment with methyl donors cocktail were treated with 200 μL cocktail for 4 days. After finishing the treatment, both untreated and treated animal lots were injected with 150 μCi [Methyl-3H]-Thymidine. Biodistribution studies were performed at 2, 4 and 8 hours post injection. The biodistribution results showed that at tumor level the uptake of [Methyl-3H]Thymidine is higher in the untreated animals (0.78%ID/g at 2 h, 1.07%ID/g at 4 h and 1.35%ID/g at 8 h) than in treated animals (0.06%ID/g at 2 h, 0.11%ID/g at 4 h and 0.13%ID/g at 8 h). The results regarding the Homocysteine levels in investigated animals show a decreasing of Homocysteine concentration up to normal values for treated animals.
