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  • Author or Editor: W. Feindel x
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This paper decribes syntheses for the11C-labelled chemotherapeutic drug, CCNU,11C-labelled BFNU and CFNU (analogs of BCNU) as well as an improved synthesis for11C-BCNU. Also discussed are procedures for the separation of dual isomers in the case of11C-labelled CCNU and CFNU. The specific activity of these no-carrier-added radiopharmaceuticals was approximately 104 lower than expected for a carrier-free product. The syntheses were normally finished 20–25 min after the end of the collection of11C-COCl2. Chemical and radiochemical purity of the final product, as determined by HPLC and TLRC respectively, was at least 98%. The syntheses yielded 10–25 mCi of nitrosourea ready for use in PET studies.

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