The rheological properties of seven winter wheat cultivars from two harvest years were studied. Rheological testing included two empirical rheological methods, alveograph and extensograph. Principal component analysis on the studied rheological parameters showed that the alveograph and extensograph parameters are influenced by entirely different factors. The first component was responsible solely for the extensograph parameters, primarily for the resistance properties of dough samples. The second component affected the extensograph extensibility (E) and alveograph tenacity (P) parameters as well, in spite of the fact that these parameters refer to different properties of dough. The third component explained only alveograph parameters, such as P, L and G values. The Pearson’s correlation coefficients showed that the extensograph area parameter primarily depends on the maximum resistance to extension of dough (r=0.91). The extensibility and resistance at a constant extension of 5 cm properties did not show such strong relationship with the area parameter (r=0.56 and 0.65, respectively). The relationship between the extensograph maximum resistance and extensibility parameters was positive (r=0.20), while the correlation coefficient between alveograph P and L value was negative (r=0.34).
Because of similar pathophysiologic changes, oleic acid (OA)-induced pulmonary edema has been well established as an experimental model of certain types of ARDS. Data in the literature indicate changes mostly in global pulmonary mechanical parameters (lung resistance and compliance) during permeability-type edema. Therefore, we designed this study (1) to separate the OA-induced mechanical responses into airway and parenchymal components, and (2) to examine the relationship between the mechanical parameters and the degree of edema. Anaesthetized, paralyzed, mechanically ventilated rats were given iv. OA in doses of 0 (C n=9), 0.05 (OA0.05 n=8), 0.1 (OA0.1 n=10) and 0.3 (OA0.3 n=5) ml/kg. Respiratory system impedance was measured with a wave-tube low-frequency forced oscillation technique, and a model fitting was used to estimate airway (Raw) and lung tissue parameters (G, parenchymal damping; H, elastance). Pulmonary edema was quantified by gravimetric analysis (WW/DW, wet-to-dry weight ratio). In the OAL0.05 group, transient, but significant increase in Raw, only slight increase in H, and no response in G was observed. Different responses were obtained in OA0.1: significant Raw, G, and H values in survivors; rapid and significantly higher responses in all three parameters in non-survivors. Extremely large parameter values were measured in OA0.3. We found that OA caused dose-related increases in WW, DW and WW/DW. Highly significant correlations were found between the degree of edema and G or H, but not Raw. This study demonstrates that low dose of OA had only transient lung mechanical effects; however, it resulted in mild edema. The higher dose elicited significant airway and tissue changes (smaller responses in survivors than in non-survivors), and severe edema. The strong correlation between lung tissue parameters and the degree of edema suggests that the OA-induced acute lung injury is manifested primarily in the alterations in parenchymal mechanics.
Authors:I. Boros, G. Horváth, S. Lehel, T. Márián, Z. Kovács, J. Szentmiklósi, G. Tóth, and L. Trón
[11C]-labeled form of ten A2a adenosine receptor specific 8-styryl-7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N-methylation of the corresponding 8-styryl-xanthine derivatives using [11C]-methyl iodide in optimized reaction conditions. The results show that the [11C]-methylations take place with excellent radiochemical yields (35–93%), and can be utilised easily in online preparations.
These labeled ligands may facilitate the positron emission tomographic (PET) investigation of adenosine A2a receptors.
Authors:Z.P. Zomborszki, W. Peschel, K. Boros, J. Hohmann, and D. Csupor
Withania somnifera (L.) Dunal originates mainly from Northern and Southern India. Primarily the roots are used in the Ayurvedic medicine as tonic, sedative hypnotic, adstringent, diuretic, emetic, and aphrodisiac. In Europe, it is widely used in food supplements. Due to the many effects and uses of this plant, the analysis of the Withania somnifera and optimization of industrial processing is nowadays an important issue. In Europe W. frutescens is native, and may be interesting for industrial preparation due to its similar phytochemical profile to W. somnifera. The point of our research was to develop an effective extraction and hydrolysis method of the Withania frutescens leaves to optimize the industrial processing.
Authors:K. Szakszon, Z. L. Veres, M. Boros, S. Sz. Kiss, B. Nagy, E. Bálega, á. Papp, E. Németh, I. Pataki, and T. Szabó
We report a case of an infant with spontaneous chylothorax due to the congenital malformation of a small lymph vessel of the chest wall. Conservative therapy with omitting long-chain fatty acids from the diet, fat-free nutrition, total parenteral nutrition and intravenous somatostatin did not result in the decrease of pleural effusion. Thoracic surgical intervention performing thoracic duct ligation and using fibrin sealants was applied after 10 days of unsuccessful conservative therapy, and resulted in the complete recovery of the patient. Our experience support the already existing observations, that in cases where the daily loss of chyle exceeds 100 ml per age years and/or lasts longer than 2 weeks, early surgical intervention is recommended.