The academic level and scientific reputation is the most important merit of a research university. Publication of the scientific achievement in the world leading scientific journals is the key to asses a university's overall performance. Peking University is a leading university among the Chinese research universities, and the number of papers published in Science Citation Index (SCI) indexed journals has been on the top of the national list. In this paper, based on our long-term experience and practice in scientific management, we use scientometrics and informetrics method to analyze the academic performance of the researchers, departments and schools of Peking University, mainly using the citations of publications. Highly cited papers are specially important to the reputation of our university. We compare those data with some selected world well-known universities, hence, some important information can be deduced for the policy decision of the university. The results presented here is not only an academic survey, but also a guideline for the future strategic development of Peking University.
Authors:Jun Yuan, Wei Yue, Cheng Su, Zheng Wu, Zheng Ma, Yun Pan, Nan Ma, Zhi Hu, Fei Shi, Zheng Yu, and Yi Wu
This research intends to investigate the patent activity on water pollution and treatment in China (1985–2007), and then compares
the results with patents data about Triadic patents, South Korea, Brazil and India over the same periods, patents data were
collected from Derwent World Patents Index between 1985 and May 2008. For this study, 169,312 patents were chosen and examined.
Total volume of patents, technology focus, assignee sector, priority date and the comparison with other countries are analyzed.
It is found that patents on water pollution and treatment filed at China have experienced a remarkable increase and the increase
rate of patents filed at China change simultaneous with the percentage of domestic applications. However, the number of high
quality Triadic patents with priority country as China remains small. Furthermore, in addition to individual patent assignees,
both Chinese universities and enterprises also play important roles in patent activity of water pollution and treatment. In
addition, the pattern of South Korea’s development can provide short-term implications for China and the regularity in Triadic
patents’ development can provide some guidance to China’s long-term development. In contrast, the development pattern of Brazil
and India is less influential to China’s development. Furthermore, China’s technology focuses on water pollution and treatment
seem to parallel global and triadic patent trends. This research provides a comprehensive picture of China’s innovation capability
in the area of water pollution and treatment. It will help China’s local governments to improve their regional S&T capability
and will provide support the National Water Pollution Control and Treatment Project in China.
8-O-Acetylharpagide is the main active component of the herb Ajuga decumbens, which possesses anti-tumor, anti-virus, and anti-inflammation properties. In this study, ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was used to measure the concentration of 8-O-acetylharpagide in mouse blood, with subsequent investigation of the pharmacokinetics of the drug after intravenous or oral administration. Shanzhiside methyl ester was used as an internal standard, and the acetonitrile precipitation method was used to process the blood samples. Chromatographic separation was achieved using an ultra-performance liquid chromatography ethylene-bridged hybrid (UPLC BEH) column (2.1 mm × 50 mm, 1.7 μm) with a gradient methanol–water mobile phase (containing 0.1% formic acid). The flow rate was 0.4 mL/min, and the elution time was 5.0 min. 8-O-Acetylharpagide was quantitatively measured using electrospray ionization (ESI) tandem mass spectrometry in multiple reaction monitoring (MRM) mode with positive ionization. The result indicated that, within the range of 5–500 ng/mL, the linearity of 8-O-acetylharpagide in mouse blood was satisfactory (r > 0.995), and the lower limit of quantification (LLOQ) was 5 ng/mL. Intra-day precision relative standard deviation (RSD) of 8-O-acetylharpagide in blood was lower than 9%, and the inter-day precision RSD was lower than 13%. The accuracy range was between 94.3% and 107.1%, average recovery was higher than 91.3%, and the matrix effect was between 100.8% and 110.8%. This analytical method was sensitive and fast with good selectivity and was successfully applied to perform pharmacokinetic studies of 8-O-acetylharpagide in mice. The bioavailability of 8-O-acetylharpagide was 10.8%, and the analysis of the primary pharmacokinetic parameters after oral and intravenous administration indicated that 8-O-acetylharpagide had a significant first pass effect after oral administration.
Authors:Jing Zheng, Wanchun Zhu, Chunxiang Ma, Yazhuo Hou, Wenxiang Zhang, and Zhenlu Wang
The catalytic properties of supported Cu/SBA-15 catalysts prepared by the ion-exchange method were investigated for the hydrogenolysis
of glycerol in a fixed-bed tubular reactor. The Cu/SBA-15 catalyst performed higher selectivity to 1,2-propanediol and high
stability. We propose that the larger specific surface area and the ordered mesoporous channels of SBA-15 may play important
roles in stabilizing highly dispersed copper species, and forming an active and durable catalyst for the title reaction.
Authors:Shao-Ning Yu, Zheng-Ping Fan, Li Ma, Yan-Zhao Yang, and Bo-Rong Bao
The influence of the concentration of nitric, hydrochloric and phosphoric acids, petroleum sulfoxides (PSO), salting-out agent,
kind of diluent and temperature on the distribution ratio of U(VI) and Th(IV) has been systematically studied. It is found
that the extraction regularity of PSO is similar to that of TBP. The distribution ratio in phosphoric acid is lower, but it
increases with the increase of hydrochloric acid concentration and reaches a high value. The U(VI) exhibits the maximum distribution
ratio at 3–4 mol/l HNO3. The distribution ratio of U(VI) and Th(IV) increases rapidly in the presence of a salting out agent. The extracted compounds
are determined to be UO2(NO3)22PSO and Th(NO3)42PSO. The extraction enthalpies of U(VI) and Th(IV) with PSO were also calculated.
Authors:Yishan Wu, Yuntao Pan, Yuhua Zhang, Zheng Ma, Jingan Pang, Hong Guo, Bo Xu, and Zhiqing Yang
This paper traces the history of China Scientific and Technical Papers and Citations database (CSTPC) since its founding in 1988. The fact that most Chinese scientists publish their research results in Chinese journals requires that China establish SCI counterparts dedicated to domestic S & T journals. The article describes the selection criteria for source journals, the approach used to adjust the structure of source journals, the criteria for selecting items to be included in the database, and the indexing method. Then it discusses the impact upon government R & D administration agencies and the science community in general by both CSTPC team and CSTPC database. Finally, the article analyzes the main factors that lead to the primary success of CSTPD. The authors encourages information workers in other non-English developing countries to build up similar databases.
Authors:Yanjiang Han, Duanzhi Yin, Mingqiang Zheng, Wei Zhou, ZhenHong Lee, Lan Zhan, Yufei Ma, Mingxing Wu, Lingli Shi, Ni Wang, Jianbo Lee, Cheng Wang, Zheng Lee, and Yongxian Wang
The aim of this study was to develop a radiopharmaceutical for the imaging of CXCR4-expressing tumors in vivo. For 125I-labeling, 125I-SIB was synthesized and conjugated with the ε-NH2 group of Ac-TZ14011, a specific CXCR4 antagonist. The specific radioactivity of the product was 5 GBq/μmol and the radiochemical
purity (RCP) was 96% (n = 3). After 6 h, the RCP of the product in PBS was 93%. The MCF-7 cell uptake of Ac-TZ14011 was rapid and high. Primary biodistribution
studies indicated that 125I-IB-Ac-TZ14011 was mainly excreted via the kidney, and further evaluation in mice with induced tumors was necessary.
Aegilops sharonensis (Sharon goatgrass) is a valuable source of novel high molecular weight glutenin subunits, resistance to wheat rust, powdery mildew, and insect pests. In this study, we successfully hybridized Ae. sharonensis as the pollen parent to common wheat and obtained backcross derivatives. F1 intergeneric hybrids were verified using morphological observation and cytological and molecular analyses. The phenotypes of the hybrid plants were intermediate between Ae. sharonensis and common wheat. Observations of mitosis in root tip cells and meiosis in pollen mother cells revealed that the F1 hybrids possessed 28 chromosomes. Chromosome pairing at metaphase I of the pollen mother cells in the F1 hybrid plants was low, and the meiotic configuration was 25.94 I + 1.03 II (rod). Two pairs of primers were screened out from 150 simple sequence repeat markers, and primer WMC634 was used to identified the presence of the genome of Ae. sharonensis. Sequencing results showed that the F1 hybrids contained the Ssh genome of Ae. sharonensis. The sodium dodecyl sulfate polyacrylamide gel electrophoresis profile showed that the alien high molecular weight glutenin subunits of Ae. sharonensis were transferred into the F1 and backcross derivatives. The new wheat-Ae. sharonensis derivatives that we have produced will be valuable for increasing resistance to various diseases of wheat and for improving the quality of bread wheat.