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Orvosi Hetilap
Authors: Márton Koch, Katalin Tímea Török, Ferenc Nagy, Viktor Soós, Éva Pozsgai, Zsuzsanna Lelovics, Anna Nagy and Csaba Varga

. 16 Kuczmog Z. Examination of virulence markers of West Nile virus. [A nyugat-nílusi vírus virulencia markereinek vizsgálata.] Thesis. Budapest, 2014. [Hungarian

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Orvosi Hetilap
Authors: Gergely György Nagy, Zsuzsa Tudlik, Lajos Gergely, József Kónya, Piroska Orosi, Éva Rákóczi, Judit Szabó, Csaba Várvölgyi, Eszter Vitális and György Paragh

virulence and zoonotic potential of Streptococcus suis . Sci Rep. 2016; 6: 28984. 4 Liu H, Gao XY, Fu SH, et al. Molecular evolution of emerging

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of sepsis . Virulence 5 , 154 – 160 . Bonelli , F. , Meucci , V. , Divers , T. J. , Boccardo , A. , Pravettoni , D. , Meylan , M. , Belloli , A. G. and Sgorbini , M

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[ 11–14 ]. In contrast to adult patients, the patients below 20 years of age usually experienced relatively mild symptoms and had a shorter duration of infection [ 11, 12, 15, 16 ]. Both children and adults were exposed to the same virulence of SARS

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The association between putative virulence genes in Campylobacter jejuni clinical isolates, in vitro invasive capability and severity of infection is yet to be clearly described. We have characterized three virulence genes and correlated their presence with the severity of infection and in vitro invasiveness. We studied eight C. jejuni strains isolated from patients whose clinical data were scored to determine severity of infection. Cytolethal distending toxin (cdtB) , invasion associated marker (iam) and Campylobacter invasion antigen (ciaB) genes were detected by PCR and INT407 cells used for invasion assays. Two strains positive for all three genes were the most invasive and isolated from patients with the most severe infection. Four strains positive for two genes and two strains negative for all the three genes were identified. The two cdtB + ve / ciaB + ve strains were more invasive than the cdtB + ve / iam + ve strains. One of the cdtB ve / ciaB ve strains showed invasion levels similar to cdtB + ve / ciaB + ve strains, but the second strain had a non-invasive phenotype. The findings indicate a correlation between in vitro invasive capability, and the presence of all three genes. The pattern of association between invasiveness and molecular characterization suggests that the ciaB gene confers a more invasive capability.

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. , Koch , G. , Rottier , P. J. and Peeters , B. P. ( 2011 ): Virulence of Newcastle disease virus: what is known so far? . Vet. Res. 42 , 1 – 11 . Ezema , W. S. , Eze , D. C. , Shoyinka , S. V. O. and Okoye , J. O. A. ( 2016

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can be transferred between bacteria, along with other antibacterial resistance genes and virulence genes ( Leinweber et al., 2018; Pinholt et al., 2019 ). van A plasmids have been characterised in VREfm from wild birds ( Oravcová et al., 2018 ) and

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AC , Yu WH , The human oral microbiome . J Bacteriol 2010 ; 192 : 5002 – 5017 . 10.1128/JB.00542-10 [4] Huang R , Li M , Gregory R . Bacterial interactions in dental biofilm . Virulence 2011 ; 2 : 435 – 444 . 10.4161/viru.2

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pathogen . J Clin Outcomes Manag 2010 ; 17 : 363 – 369 . [2] Jahangiri S , Malekzadegan Y , Motamedifar M , Hadi N . Virulence genes profile and biofilm formation ability of Acinetobacter baumannii strains isolated from inpatients of a

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virulence of the virus, on crowded places, on the hygiene and behaviour of the person, and on co-infection with other pathogens [ 18 ]. Diagnosis Diagnosis is based on clinical findings and demonstration of the virus RNA. Detecting antibodies generated

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