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Authors: Sujata G. Dastidar, Sanchayita Debnath, Kaushiki Mazumdar, Kumkum Ganguly and A. N. Chakrabarty

The antipsychotic phenothiazine triflupromazine, possessing a methyl-thio substituent at position 10 and a fluorine moiety at position 2, exhibited significant antibacterial activity against 279 strains of Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration (MIC) of the drug, according to the agar dilution method, was between 2 and 50 µg/ml for Staphylococcus aureus, and 5 and 100 µg/ml for shigellae and vibrios. Triflupromazine, when injected intraperitoneally into Swiss albino mice at a concentration of 30 µg/mouse (20 g), manifested a significant protection to the mice (p<0.001) when they were challenged with 50 median lethal dose (MLD) of Salmonella typhimurium NCTC 74. Moreover, there was a statistically significant reduction in the number of viable bacteria in organ homogenates and blood of mice treated with this phenothiazine compound.

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Summary

Aripiprazole is a novel atypical antipsychotic drug used in the treatment of schizophrenia. The sensitive and reproducible ion pair RPLC method was developed and validated for determination of aripiprazole and its nine impurities, which are significantly different in polarity. The separation was performed on Phenomenex Luna® C18 column (5.0 μm particle size, 250 × 4.6 mm id) using a gradient mobile phase A (phosphate buffer pH 3.0) and mobile phase B (acetonitrile) at the working temperature of 25°C. The buffer was 1.11 g KH2PO4 with 1.2 g sodium pentanesulfonate/L of the solution, adjusted to pH 3.0 with orthophosphoric acid. The flow rate was 1.0 mL/min. The detection was carried out at 215 nm using a diode array detector. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines for specificity, limit of detection, limit of quantification, linearity, precision and robustness. The proposed method is convenient and reliable for the purity control in both raw materials and dosage forms.

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Authors: László Tombor, Pál Salacz, Éva Jankelovics and Zoltán Hidasi

Absztrakt:

A szerzők pszichiátriai tünetekkel járó neuroszifiliszes esetet közölnek. Az idősödő férfit zavart, kritikátlan viselkedés, mániform állapot és megalomán téveszmék miatt vettük fel az első alkalommal. Felvételkor jobb centrális facialis paresis, tremor és parkinsonismus volt észlelhető. Akut képalkotó és rutin laborvizsgálatok a tudatzavart egyértelműen magyarázó eltérést nem igazoltak. A pszichiátriai kezelés hatására a delírium megszűnt. Ezután antipszichotikummal kezelt mániform állapot dominálta a képet, majd gyors kognitív leépülést és a motoros tünetek progresszióját észleltük. A koponya-MRI-vizsgálat corticalis és hippocampusatrophiát, fehérállományi hiperintenzitásokat talált. A liquorban pleocytosist, emelkedett összfehérjeszintet találtunk; a neuroszifilisz diagnózisát szerológiai vizsgálatokkal támasztottuk alá. Penicillinkezelést követően a kognitív tünetek enyhültek, a pszichiátriai tünetek remisszióba kerültek. Négy évvel a diagnózist követően a kognitív hanyatlás fokozatos progressziót mutat, a pszichiátriai tünetek relapsusa miatt két további alkalommal volt szükség osztályos felvételre. Orv Hetil. 2018; 159(6): 234–238.

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D. R.A. Uges, J.M.H. Conemans , Antidepressants and antipsychotics: Handbook of analytical separations. Elsevier, Amsterdam, 2000. Conemans J

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Allison, D. B., Casey, D. E.: Antipsychotic-induced weight gain: a review of the literature. J. Clin. Psychiatry, 2001, 62 (Suppl. 7) , 22–31. Casey D. E. Antipsychotic-induced weight

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antipsychotic. Neuropsychopharmacology 30, 1963–1985 (2005) Scatton B. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1

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Authors: János Tomcsányi and Kristóf Tomcsányi

margin of an antipsychotic drug haloperidol for torsade de pointes using the chronic atrioventricular block dogs. Cardiovasc Toxicol. 2017; 17: 319–325.

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Authors: Şule Seçkin, Şeyda Alsancak, Canan Başaran-Küçükgergin and Müjdat Uysal

antipsychotics and other psychoactive agents to the calcium dependent activator of cyclic nucleotide phosphodiesterase. J. Pharmacol. Exp. Ther. 208 , 454–458. Weiss B. Selective binding

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] R. Valarmathi , S. Akilandeswari , D. Dhharshini , S. Farishabanu , R. Senthamarai , Atypical antipsychotic drug - quetiapine fumarate and its analytical techniques , Int. J. Pharm. Chem. Sci. 2 ( 2013 ) 197

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: Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong. Keoi J. Med., 2006, 55(1) , 9–14. Kan C. S. Anti-psychotics adherence among out-patients with

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