Authors:Z Kojić, Z Kojić, Z Kojić, Lj Šćepanović, Lj Šćepanović, Lj Šćepanović, N Popović, N Popović and N Popović
In our previous work
we have shown that in mouse heart basal level of endothelial produced
nitrite, as a marker of nitric oxide (NO) formation, was 9.7 nmol l-1.
Bradykinin (10 mmol l-1)
induced a 5-fold rise in nitrite release, the coronary venous effluent
concentration being 58 nmol l-1, but there was no effect on
myocardial oxygen consumption (MVO2). The aim of this study was to
assess the levels of authentic nitric oxide solution, exogenously applied, on
myocardial oxygen consumption. Isolated mouse hearts (n=36) were paced (500
imp./min) and perfused at constant flow (16.0±0.3 ml g-1 min-1). When
coronary vasculature resistance was carefully controlled by adenosine (1 mmol l-1), authentic nitric oxide
solution, in a concentration less than 5 mmol l-1 did not alter myocardial oxygen
consumption. Only concentrations of nitric oxide higher than 5 mmol l-1 induced reduction in myocardial
oxygen consumption. Thus in the saline perfused mouse heart, with carefully
controlled vasodilatation, modulating myocardial nitric oxide levels using an
arterial application of authentic nitric oxide, concentrations higher than 5 mmol l-1 of nitric oxide were required to
induce a decrease in myocardial oxygen consumption.
Molnár, M., Sütö, T., Tóth, T. és mtsa: Prolonged blockade of nitricoxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am. J. Obstet. Gynecol., 1994, 170 , 1458
., Desikan, R., Hurst, R. D., Hancock, J. T., Neill, S. J. (2000) NO way back: nitricoxide and programmed cell death in Arabidopsis thaliana suspension cultures. Plant J. 24 , 667-677.
NO way back: nitricoxide and programmed
Authors:Daniya Rakhmatullina, Alexander Alyabyev, Tatiana Ogorodnikova and Anastasia Ponomareva
In the past decade, the nitricoxide (NO) effect on plants metabolism has been given much consideration [ 1 , 2 ]. NO is a short-lived free radical that diffuses through membranes. NO is found in different plant