Authors:Ábel Garai, István Péntek, Attila Adamkó and Ágnes Németh
The international healthcare systems interoperability is an unresolved technological area at the moment. This paper demonstrates the results of the software engineering research for simplex syntactic and semantic technical interoperability of hospital information systems, eHealth smart device technology and clinical telemedicine instruments through the recently developed Telemedicine Interoperability Hub. Several similar experiments exist. This research is unique in building a prototype interconnecting not only healthcare information systems with each other, but aiming to establish a general healthcare interoperability scheme including also the eHealth smart devices and telemedicine instruments. The aim of this research is to establish cloud-based data interchange capability with the newly developed information technology system interconnected with the emerging eHealth Internet of Things solutions and the classical hospital information system architecture. Notwithstanding the international information technology medical data exchange standards, like Health Level Seven, the adoption of an industry-wide open telemedicine syntactic and semantic interoperability standard is necessary. The research studied varying simplex, duplex, full-duplex, data package- and file-based information technology modalities establishing stable system interconnection among clinical instruments, healthcare systems and eHealth smart devices. This research is the manifestation of the trilateral cooperation of the University of Debrecen Department of Information Technology, Semmelweis University Second Paediatric Clinic and T-Systems Healthcare Competence Center Central and Eastern Europe. The developed experimental software engineering solution was embedded in hybrid cloud architecture after testing private cloud Infrastructure-as-a-Service and Public Cloud Software-as-a-Service technical solutions.
The parameters of the Arrhenius equation determined by the linear, weighted linear and non-linear least squares methods and by the simplex method are compared. Since the non-linear least squares method permits the consideration of statistical weights of both the dependent (k) and independent (T) variables and does not involve logarithmic transformation, it is advisable to calculate the parameters of the Arrhenius equation by means of the non-linear least squares method.
The eco-morphological adaptation of the pupal stages of some Polish Thripidae has been investigated in the laboratory. The propupa and pupa of species developing in grass inflorescences or in narrow cravices of leaf sheaths (Chirothrips pallidicornis, Iridothrips iridis) are characterized by shorter setae and smaller abdominal thorns than species developing on leaf blades or in flowers (Frankliniella tenuicornis, F. intonsa, Pezothrips dianthi, Thrips fulvipes, T. fuscipennis, T. menyanthidis, T. physapus, T roepkei, T. sambuci, T. simplex). Species feeding on monocots pupate and molt on their hosts as do the folicolous species feeding on dicots. In contrast, the floricolous ones feeding on dicots drop off the hosts and develop in the soil. Variation in the shape of the abdominal apical projection of the pupal stages of the female are described.
Authors:K. Kis, P. Taylor, G. Wittmann, B. Toronyi and S. Puszta
In this study we interpret the magnetic anomalies at satellite altitude over a part of Europe and the Pannonian Basin. These anomalies are derived from the total magnetic measurements from the CHAMP satellite. The anomalies are reduced to an elevation of 324 km. An inversion method is used to interpret the total magnetic anomalies over the Pannonian Basin. A three dimensional triangular model is used in the inversion. Two parameter distributions, Laplacian and Gaussian are investigated. The regularized inversion is numerically calculated with the Simplex and Simulated Annealing methods and the anomalous source is located in the upper crust. A probable source of the magnetization is due to the exsolution of the hematite-ilmenite minerals.
This article presents a new theory of simplex numerals that incorporates a slight revision of Chomsky’s (2008) set-theoretic conception of natural number, which assumes that the notion of natural number is innate. The new theory makes it possible to account for the behavior of numerals in counting as well as the developmental stages that children go through in learning numerals. The key idea is that set-theoretic objects corresponding to natural number notions are subject to operations that apply when a syntactic object is converted to phonological form. These operations provide a crucial link that connects the meaning of a numeral with the count list consisting of numerals. A notable feature of the proposed analysis is that the Cardinal Principle is derived by recruiting linguistic computation and therefore is no longer stipulated as such.
Authors:Yasemin Baskin, Z. Yazici, H. Baskin, A. Ozkul, Nur Olgun and I. H. Bahar
. (1999): Induction and prevention of apoptosis in human HEp-2 cells by herpes simplex virus type 1. J. Virol. 73, 10359-10370.
Induction and prevention of apoptosis in human HEp-2 cells by herpes simplex virus type 1
Authors:Adauto Chiamenti, Cristiano Filho, Marcelo Moura, Fabíola Paula-Lopes, Jairo Neves, Cícero Neto, Paulo Gonçalves, Paulo Lima and Marcos Oliveira
Experiments were carried out to investigate the beneficial effects of retinyl acetate (RAc) and retinoic acid (RA) on goat oocyte maturation as well as the effects of insulin-like growth factor-I (IGF-I), RAc and RA during embryo culture under chemically defined conditions. In Experiment 1, in vitro maturation (IVM) was performed in a chemically defined basic maturation medium (bMM) supplemented with 0.3 μM RAc or 0.5 μM RA. Presumptive zygotes and embryos (2–4 cells) were cultured in droplets of potassium simplex optimised medium (KSOM); however, none of the embryos reached the blastocyst stage. In Experiment 2, oocytes were matured in bMM + RAc or bMM + RA. Presumptive zygotes and 2- to 4-cell embryos were placed in fresh KSOM droplets supplemented with RAc, RA, IGF-I, RAc+IGF-I or RA+IGF-I. In Experiment 1, addition of RAc and RA to bMM increased (P < 0.05) the proportion of 2- to 4-cell embryos reaching the morula stage as compared to the control. In Experiment 2, supplementation of embryo culture media with retinoids and IGF-I increased (P < 0.05) the proportion of 2- to 4-cell stage embryos developing to the morula and blastocyst stage. Our data demonstrate that goat embryo production in chemically defined media could be improved by exogenous RAc or RA and by the interaction between retinoids and IGF-I, and that goat embryos can be produced in vitro from oocytes following protocols similar to those currently used for cattle.
Authors:B. Özcelik, I. Orhan, M. Kartal and B. Konuklugil
The objective of this study was to examine antibacterial, antifungal and antiviral properties of selected
species (Lamiaceae) growing in Turkey. The petroleum ether and methanol extracts of the seven species, namely
P.H. Davis & Hub.-Mor.,
Sibth. & Sm.,
Velen. were tested against
Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Bacillus subtilis
for their antibacterial activity using ampicillin and oflaxocin as references. Antifungal activity of the same extracts was determined against
using microdilution method with ketocanazole as reference. Both DNA virus
type-1 (HSV-1) and RNA virus
(PI-3) were employed for antiviral assessment of the
extracts using Madin-Darby Bovine Kidney and Vero cell lines in which acyclovir for HSV-1 and oseltamivir for PI-3 were employed as reference drugs. Although both the petroleum ether and methanol extracts seemed to exert similar antibacterial activity, the methanolic extracts were observed to be more active against
. On the other hand, methanolic extract of
possessed notable antiviral activity against both type of viruses.