Attempts from the 17th century onward anticipate the 20th-century mood of legal mapping. They classify legal arrangements by languages, races and genetic roots, then by their ideologies and technicalities. Later on they do so by separating the Western from the Soviet/socialist law, by their correspondence to underlying general cultures, as well as according to legal families. It is the insufficiency of resorting to dichotomy contrasting the Western “Us” to any differing Eastern “Others” that has recently resulted in typologising in terms of the dynamism and directions of legal development in the duality of professionalism and traditionalism or in the cross-reference of what is established/stable and unestablished/instable, and of what is drawn from Western and non-Western sources. Material taxonomy cannot be accomplished in law through genuine class-concepts. Characterisation through concepts of order can be achieved at most. In want of any meta-system, cultures formed to idealise and hypostasise ideas of order by independent principles can provide no common basis of division for law. Accordingly, only some division to major and minor sets and subsets can be achieved. The own arrangement will be better cognised by other schemes’ understanding. The gradual transcendence of rule-fetishism by identifying law with some specific culture may prevent the coming “clash of civilizations” from reaching aggressive self-assertion and care for the sustainability of the laws’ diversity.
During the analysis of the protagonist's (namely, Sharik's and Sharikov's) way of speaking in Bulgakov's story Heart of a Dog, an abrupt contrast or even a complete oppositeness of the constituents becomes apparent. In its turn, this provides the base and evidence for this ultimate oppositeness of the protagonists in the story in general. Sharikov's speech is mainly characterized by the following features: 1) absence of skills of monological speech manifested by the violation of norms of constructing sentences and by the tendency towards using short and concise sentences, 2) violation of lexical and grammatical norms, 3) abundance in colloquialisms, 4) frequency of generalized and demagogic constructions, 5) presence of officialese and ideological clichés. It is Sharikov's speech and his way of speaking that enables the reader to make conclusions about his figure in general, and determine the most important characteristic features of his inner self which are as follows: 1) low cultural level, 2) aggressiveness and growing confidence in his own right, 3) belonging to the layer of uneducated, uncivilized and often declassed people.
Authors:L. Majoros, G. Kardos, I. Pócsi and B. Szabó
Data of Candida albicans and non-albicans Candida species isolated during the 1997-2000 period in the Medical and Health Science Center of the University of Debrecen are analysed. The number of yeast isolates increased from 408 to 1213 per year during this period. Dominance of C. albicans has been persistent, but a slight increase of C. glabrata and C. krusei could be observed. Distribution of different Candida species isolated from 16 body sites indicates that C. albicans seems to be still the most aggressive Candida species. Investigation of 244 urinary Candida isolates (parallel with bacterial cultures) suggests that tha aetiological role of Candida species in the pathogenesis of urinary tract infections can be hypothesized if colony forming unit (CFU) number of yeasts is higher than 104/ml and bacteria are present in low CFU number or are absent. Antifungal susceptibility testing of C. albicans, C. glabrata, C. tropicalis and C. krusei against Flucytosine, Amphotericin-B, Miconazole, Ketoconazole and Fluconazole suggests that Amphotericin-B is still the most effective antifungal agent. Finally, the problems in judging the aetiological role of isolated Candida species in the pathogenesis of different types of diseases are critically discussed.
Experimental models that mimic the clinical syndrome of human viral encephalitis and represent HSV-1 neurotropism were utilized to investigate neuro-pharmacologic changes mediating clinical and behavioral manifestations of encephalitic infection of the central nervous system with HSV-1-induced rapid activation of the hypothalamic - pituitary - adrenocortical (HPA) axis and production of brain derived interleukin-1 (IL-1) and prostaglandin E2 (PG-E2), independently of viral replication. HSV-1 infection induced clinical signs of fever, motor hyperactivity and aggressive behavior. These manifestations were dependent on a permissive action of circulating glucocorticoids and not related to the degree of viral replication in the brain. Hyperthermia and HPA axis activation were also specifically dependent on HSV-1-induced brain IL-1 and PG-E2. The chronic neurological sequel or fatal outcome of HSV-1 encephalitis may be due to viral replication and brain tissue destruction, which are dependent on virus encoded virulence genes. In contrast, the clinical and behavioral signs in the acute phase are a result of activation of neurochemical systems, including cytokines, prostaglandinds and catecholamines. Circulating glucocorticoids play an essential role in mediating the physiologic actions of HSV-1-induced brain products and the clinical syndrome of encephalitis.
Authors:E. Tabar, F. Lambrecht, C. Gunduz and M. Yucebas
Radiolabeled molecules have an important role to evaluate tumor characteristics such as aggressiveness, and to identify the
effectiveness of cancer treatments such as chemotherapy and radiotherapy. Various radionuclide (18F, 99mTc, 124I) labeled molecules can be used apoptosis detection by estimating decrescendos cell viability after therapy. 99mTc-tetrofosmin which is used as a myocardial perfusion imaging agent in routine and at the same time is known to accumulate
in various tumors including breast tumor. The aim of this study was to assess the utility of 99mTc-tetrofosmin for monitoring the early response of MCF-7 breast cancer to chemotherapy. To evaluate the role of 99mTc-tetrofosmin in vitro chemotherapy, the uptake ratio was determined using MCF-7 breast cancer line after the cells had been
treated with cisplatin. When we examined the apoptotic ratios which induced with different dose of cisplatin in MCF-7 breast
cancer cells by using Annexin V and TUNEL methods, it was observed that the rate of apoptosis increased with soaring dose.
The uptake rates of 99mTc-tetrofosmin in MCF-7 cell line in the chemotherapeutic groups were lower than it is in the control group (p < 0.01). The negative correlation between uptake ratios and apoptotic rates shows that 99mTc-tetrofosmin may be used a radiopharmaceutical for evaluating chemotherapy response. 99mTc-tetrofosmin might be probably useful as an imaging agent for estimation of early chemotherapy response in breast cancer.
Authors:Anikó Smudla, Zsuzsanna Gerlei, Levente Gergely, Marina Varga, Éva Toronyi, Attila Doros, Tamás Mándli, Zsuzsanna Arányi, Enikő Bán, Enikő Sárváry, László Kóbori and János Fazakas
The complications caused by the rarely viral infections are more frequently treated in ICU (intensive care unit). The world paid attention to the WNV (West Nile virus) infections only in 1999, when 62 meningoencephalitis were registered in New York State. Six cases of WNV occur annually in Hungary. The authors present the first transplanted Hungarian patient with WNV encephalitis. The patient was hospitalized with epigastric pain, diarrhea, continuous fever, and decreasing amount of urine. The first checkup of infectious diseases was without any result. Although using of empirical antimicrobal therapy, the multiorgan failure patient remained febrile. On the basis of clinical signs, meningitis or encephalitis was suspected despite negative results of repeated cultures. On the 8th day, WNV infection was confirmed by serological examinations. With intravenous immunoglobulin therapy used within confines of supportive treatment, the patient became afebrile. After 21 days in ICU with good graft function, the patient was moved to the ward and he left the hospital after two more weeks. Until now, no prophylactic or etiological treatment has been developed for WNV. The early treatment is done with immunoglobulin or interferon; otherwise therapy has only supportive function. The disease caused by virus is more aggressive in transplanted patients and could be caused death.
Authors:R.B. Rauber, P.A. Cipriotti and M.B. Collantes
Disturbances are important drivers in natural ecosystems, affecting the vegetation structure and functioning. Invasions of exotic plant species are often associated to disturbances in a complex manner, because they depend on the type, intensity, spatial and temporal arrangement of disturbances, and the particular abiotic and biotic context. Field studies that evaluate the dynamics of plant invasions under different disturbance regimes have a great importance for the understanding of the disturbance effects on invasion spread. In this work we evaluated, through a field manipulative experiment, the early colonization and expansion dynamics of an aggressive invader of grasslands, Hieracium pilosella L., under two disturbance types. We used a split-plot experiment by crossing three levels for a local, sporadic, of increasing intensity disturbance [i.e., 1- undisturbed, 2- vegetation mowing, and 3- ploughing], within two levels for an extensive and chronic disturbance (i.e., grazed and ungrazed). In the range of intensities of disturbance evaluated, the intermediate intensity (i.e., mowing) accelerated the colonization when it is grazed and the expansion of H. pilosella in ungrazed condition. In contrast, lower and higher intensity disturbances, such as ungrazed and ploughing treatments decelerated both invasion processes. Changes in resource availability, interspecific competition and particular characteristics of the invader, i.e., high light requirements, prostrate growth and the presence of stolons, could explain these early invasion patterns.
A malignus melanoma pigmentsejtekből kiinduló, későn felfedezve igen agresszív, folyamatosan növekvő incidenciájú, bármely korosztályt érintő daganatos megbetegedés. Leggyakoribb formája meglévő hajlamosító tényezők (bőr-, szem-, hajszín, anyajegyek, pozitív családi anamnézis) talaján hozzáadódó környezeti faktorok (napégés) hatására a kültakarón, vagyis minden orvos számára könnyen vizsgálható helyen alakul ki. Sikeres kezelésének alapja továbbra is a korai diagnózis és műtéti eltávolítás. Áttétek jelentkezésekor a klasszikus, bár melanoma esetén csekély sikerrel kecsegtető kemo- és sugárterápia mellett, illetve helyett ma már új, molekuláris genetikai kutatásokon alapuló célzott terápiás szerek, valamint a gátolt tumorellenes immunválaszt a fék alól felszabadító immunterápiás gyógyszerek is rendelkezésre állnak. Az összefoglaló közleményben a szerzők régi és új ismereteket igyekeznek rendszerezni és terjeszteni, bármely, a téma iránt mélyebben érdeklődő gyógyító szakma képviselőjének átnyújtani. Orv. Hetil., 2015, 156(15), 583–591.
This paper investigates cases in which people who are perceived to have violated a major communal and/or social norm are humiliated in public in a ritual way. As a case study we examine online videos drawn from the Chinese videosharing site Youku. Humiliation as a form of punishment has been thoroughly studied in sociology (see e.g., the seminal work of Foucault 1977). This interest is not coincidental, considering that studying humiliation may provide insight into the operation of shame as a punitive phenomenon, as well as the role of publicity and complex participation structures when shame is inflicted on others. Yet, punitive humiliation has been understudied in pragmatics; in particular, little research has been done on cases in which it is not an institutionally/socially ratified person (e.g., a judge) but the members of the public who inflict humilation. The study of this phenomenon contributes to the present Special Issue as it demonstrates that pragmatics provides a powerful tool to model the dynamics of (language) behaviour such as humiliation that might be difficult to capture by using more conventional linguistic approaches. We demonstrate that while ritual public communal humiliation tends to be highly aggressive, it also shows noteworthy recurrent (meta)pragmatic similarities with institutionalised forms of punishment.
Although nature looms large throughout Homer’s Odyssey, literary critics have entirely neglected to discuss his construction of the natural world in this foundational Western work.
This neglect might be the result of two factors: the blurred line between geographical and fantastical locales in Odysseus’
travels and the blurred line between natural forces and deities. This essay recognizes that Homer not only reconstructs the
Mediterranean world in his epic through detailed references to weather, geology, plants, birds, and animals but also that
his similes suggest a consciousness of inter-species relationships. Principally, however, this essay argues, as does William
Cronon, that “relationships, processes, and systems are as ecological as they are cultural,” and that Odysseus’ response to
nature may usefully be understood in relation to three ecocritical models: the anthropocentric or domination model, the stewardship
model, and the biomorphic model. His exploitative and aggressive behavior toward the Cyclopes, Circe, and the cattle of the
Sun is contrasted with his recognition upon his homecoming of his own animal nature and his appreciation of the agrarian and
pastoral life. While the tradition of writing in The Odyssey genre has vigorously continued in Western literature, only recently have contemporary environmental writers moved toward
a recognition of the threat of the anthropocentric perspective to the imperative of working toward the stewardship and biomorphic