The formation of benzynes derivatives from ortho-trimethylsilyl triflates using tetra-n-butylammonium fluoride (TBAF) as the benzyne-forming trigger was achieved in a straightforward flow reactor at room temperature. These benzynes were immediately trapped in Diels—Alder reactions to deliver the desired cycloadducts.
Authors:Mohammad Abdollahi-Alibeik and Marjan Pouriayevali
The imino Diels–Alder reaction, first explored by Povarov in 1960 [ 6 ], is one of the most important synthetic methodologies for the synthesis of six-membered nitrogen containing heterocycles.
This type of Diels–Alder reaction between
The liquid phase reaction between maleic anhydride and 1-methyl-furan leads to an exothermic cycloaddition. The reaction enthalpy,
the rate constant and the equilibrium constant are evaluated with good precision by a method of analysis using thermal data
and a dynamic model based on physical properties. The mathematical models that are presented here in a simple way (first-order
system) represent the reaction accurately and are useful for studying other reactions and even industrial processes.
Authors:Rajesh Munirathinam, Andrea Leoncini, Jurriaan Huskens, Herbert Wormeester, and Willem Verboom
.; Nakai, Y.; Ohara, N.; Yoda, H.; Takabe, K.; Tanaka, F.; Barbas, C. F. J. Am. Chem. Soc. 2005 , 128 , 734–735.
In case of the Diels–Alder reaction, a direct comparison of the wall-coated versus the packed-bed approach results
Authors:G. Scheltjens, J. Brancart, I. De Graeve, B. Van Mele, H. Terryn, and G. Van Assche
dispersed catalyst heals the material and prevents further crack growth.
A different approach is based on the incorporation of reversible cross-linking functionalities in the polymer backbone, such as Diels–Alder (DA) adducts. Wouters et al. [ 9
“Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction”R. E. Martin, * M. Lenz, T. Alzieu, J. D. Aebi, L. Forzy Tetrahedron Letters 2013 , 54 , 6703
-oxazoline) triblock copolymer synthesis in a microfluidic reactor cascade ” E. Baeten , B. Verbraeken , R. Hoogenboom , T. Junkers Chemical Communications 2015 , 51 , 11701 – 11704
“ Continuous flow of nitroso Diels–Alder