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factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet., 2006, 38 , 320–323. Reynisdottir I. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of

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Orvosi Hetilap
Authors: András Bánvölgyi, Eszter Balla, Péter Bognár, Béla Tóth, Eszter Ostorházi, Dénes Bánhegyi, Sarolta Kárpáti, and Márta Marschalkó

serovar l2 proctitis in The Netherlands among men who have sex with men. Clin. Infect. Dis., 2004, 39 (7), 996–1003. Ward, H., Martin, I., Macdonald, N., et al.: Lymphogranuloma venereum in the United Kingdom. Clin

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Interventional Medicine and Applied Science
Authors: András Mihály Boros, Péter Perge, Klaudia Vivien Nagy, Astrid Apor, Zsolt Bagyura, Endre Zima, Levente Molnár, Tamás Tahin, Dávid Becker, László Gellér, Béla Merkely, and Gábor Széplaki

Background

Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such as serum uric acid, blood urea nitrogen (BUN), albumin, cholesterol, or various liver enzymes, change over time as a consequence of CRT. The aim of this prospective study was to overview these possible changes.

Methods

A total of 20 routine laboratory parameters were measured in 122 control subjects and in 129 patients with chronic heart failure before CRT, 6 months, and 2 years later.

Results

The levels of serum uric acid [before: 432 (331–516) mmol/L, 6-month: 372 (304–452) mmol/L, 2-year: 340 (290–433) mmol/L; p < 0.001] and BUN [8.3 (6.4–11.5) mmol/L, 8.0 (6.3–11.1) mmol/L, 6.8 (5.0–9.7) mmol/L; p < 0.001) reduced statistically significant. Total bilirubin underwent reduction [16 (11–23) μmol/L, 11 (7–14) μmol/L, 8 (7–13) μmol/L; p < 0.001], while albumin increased [45 (43–48) g/L, 46 (44–48) g/L, 46 (43–48) g/L; p = 0.04]. Cholesterol concentrations elevated [4.3 (3.6–5.0) mmol/L, 4.5 (3.8–5.1) mmol/L, 4.6 (3.8–5.4) mmol/L; p < 0.001] and glucose decreased [6.2 (5.6–7.2) mmol/L, 5.9 (5.1–6.7) mmol/L, 5.7 (5.1–6.8) mmol/L; p < 0.001].

Conclusions

CRT influences the levels of routinely used biomarkers suggesting improvements in renal function, liver capacity, and metabolic changes. These changes could mirror the multiorgan improvement after CRT.

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Acta Veterinaria Hungarica
Authors: Károly Erdélyi, János Gál, László Sugár, Krisztina Ursu, Petra Forgách, Levente Szeredi, and Theodora Steineck

Oval, firm, cutaneous tumours with a rough, hairless, pigmented surface, exhibiting a moderately pronounced papillary structure were detected on the abdominal skin of two young red deer ( Cervus elaphus ). One animal was shot in Lower Austria in 2004, the other at a deer farm in Hungary in 2007. Histological examination of both samples classified the tumours as fibropapillomas, showing marked proliferation of fibroblasts and connective tissue, accompanied by hyperkeratosis, parakeratosis and acanthosis of the overlaying epidermis, and occasional foci of inflammation. The distribution of cytokeratin and vimentin was characterised in the lesion. The presence of papillomavirus (PV) antigen was demonstrated by immunohistochemistry in both cases. Papillomavirus-specific DNA was successfully amplified by PCR from one sample. The obtained partial nucleotide sequence of the L2 ORF exhibited the highest critical identity values with the homologous regions of Delta-papillomaviruses, especially the Roe deer papillomavirus (93%). Phylogenetic analysis of the partial L2 ORF sequence alignment of 10 papillomaviruses by both neighbour-joining and maximum parsimony method confirmed that the Red deer PV is very closely related to the Western roe deer papillomavirus (CcPV1).

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,006.1 ± 231.3 −0.341 0.103 BUN before dialysis (mmol/L) 27.7 ± 6.5 −0.124 0.294 Serum uric acid (μmol/L) 449.1 ± 92.4 −0.097 0.461 Ca (mmol/L) 2.27 (2.19–2.47) 0.049 0.680 P (mmol/L) 2.07 (1.63–2.61) −0.323 0.105 Ca × P (mmol 2 /L 2 ) 5.467 (3.52–6.76) −0

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(g/l) 40.38 ± 5.58 SBP (mmHg) 140.21 ± 18.36 Total cholesterol (mmol/l) 4.69 ± 1.24 DBP (mmHg) 80.32 ± 9.87 LDL cholesterol (mmol/l) 2.95 ± 1.04 Pulse pressure (mmHg) 62.58 ± 18.37 HDL cholesterol (mmol/l) 1.08 ± 0.34 MAP (mmHg) 96.6 ± 11

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expression of lung epithelial L2 cells: implications in carcinogenesis. BMC Genomics 2008; 9: 115. 13 Kurasaki M, Okabe M, Saito S, et al. Histochemical characterization of silver

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, 2014, 124 (21), 291–291. 36 Yang, H., Bueso-Ramos, C., DiNardo, C., et al.: Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by

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Orvosi Hetilap
Authors: Krisztina Lukács, Pál Pánczél, and Nóra Hosszúfalusi

, Hosszufalusi N, Dinya E, et al. The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: A meta

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Acta Veterinaria Hungarica
Authors: Ervin Albert, Rita Sipos, Szilárd Jánosi, Péter Kovács, Árpád Kenéz, Adrienn Micsinai, Zsófia Noszály, and Imre Biksi

determinants of tetracycline resistance tet(K), tet(M) were amplified with primers tetK-1/tetK-2, and tetM-1/tetM-2, respectively ( Strommenger et al., 2003 ), while tet(L) was detected using primers tet(L)-2-1 and tet(L)-2-2, described by Aarestrup et al

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