Authors:M. Brito, Gabriela Barin, A. Araújo, D. de Sousa, S. Cavalcanti, Ana Lira, and Rogéria Nunes
The aim of this work was to study the effect of Lippia sidoides essential oil (LSEO) on stratum corneum lipids and the permeation of salicylic acid. DSC and FTIR spectroscopy were applied.
LSEO 1% (v/v) significantly enhanced salicylic acid flux through snake skin. According to the DSC curves changes in the transition
temperature of the lipids were observed indicating that LSEO can interact with stratum corneum. The IR spectrum of skin treated
with LSEO showed a decrease in the peak intensity for CH2 stretchings (2920–2850 cm–1) however the peak positions did not alter suggesting the extraction of the lipids.
Authors:Luciana Fernandes, W. Oliveira, J. Sztatisz, and Cs. Novák
Microencapsulation of Lippia sidoides essential oil was carried out by spray drying. Blends of maltodextrin and gum arabic were used as carrier. Spray dried microparticles
were characterized using conventional (thermogravimetry, evolved gas analysis) and combined (thermogravimetry-mass spectrometry
analysis) thermal analysis techniques in order to evaluate the abilities of carriers with different compositions in retaining
and in releasing the core vs. dynamic heating. Thermal analysis was useful to evaluate the physico-chemical interactions between
the core and carriers and to determine the protective effect of the carriers on the evaporation of essential oil.
Authors:Luciana Fernandes, W. Oliveira, J. Sztatisz, I. Szilágyi, and Cs. Novák
Inclusion complexes of Lippia sidoides essential oil and β-cyclodextrin were obtained by slurry method and its solid powdered form was prepared using spray drying.
The influence of the spray drying, as well as the different essential oil:β-cyclodextrin ratio on the characteristics of the
final product was investigated. With regard to the total oil retention 1:10 mass/mass ratio as optimal was found between the
essential oil and β-cyclodextrin.
Thermoanalytical techniques (TG, EGD, TG-MS) were used to support the formation of inclusion complex and to examine their
physicochemical properties after accelerated storage conditions. It may be assumed that the thermal properties of the complexes
were influenced not only by the different essential oil/ β-cyclodextrin ratio but also by the storage conditions. In the aspect
of their thermal stabilities, complex prepared with 1:10 m/m ratio (essential oil:β-cyclodextrin) was the most stable one.
Authors:L. Fernandes, Zs. Éhen, T. Moura, Cs. Novák, and J. Sztatisz
Thermoanalytical techniques, being rapid and un-expensive have been used for the investigation of the cyclodextrin inclusion
complexes for three decades. The conventional thermoanalytical techniques (TG and DTA/DSC) follow the thermal properties of
the uncomplexed compounds. Consequently, the inclusion complex formation as well as the liberation of the entrapped guest
cannot be followed. Monitoring the products of the thermal fragmentation of parent cyclodextrin and the included molecule(s),
applying TG-MS combined technique provides evidence concerning the inclusion complex formation, and besides, gives selective
signal to follow the decomposition of the cyclodextrin inclusion complexes. b-cyclodextrin inclusion complexes of Thymol and
Lippia sidoides Cham essential oil extract have been prepared and investigated using conventional and combined (TG-MS) thermoanalytical techniques.
The evolved gas analysis proved the inclusion complex formation between the host and guests. By the evaluation of the experimental
results the elaboration of the entrapped guests from the cyclodextrin cavity could be followed.
Authors:Ellen Denise P. Almeida, Adjane A. Costa, Mairim R. Serafini, Fábia C. Rossetti, Juliana M. Marchetti, Victor Hugo V. Sarmento, Rogéria de S. Nunes, Mário Ernesto G. Valerio, Adriano A.S. Araújo, and Ana Amélia M. Lira
, Nunes , RS . 2009 The action modes of Lippiasidoides (Cham) essential oil as penetration enhancers on snake skin . J Therm Anal Calorim. 97 : 1 323 – 327 . 10.1007/s10973-008-9669-8 .