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Abstract  

The potential of the INAA and PIXE methods for the detection of mineral microelement changes in pathological human blood serum has been evaluated on nine cases of different hemopathies. These included hereditary hemolytic anemias (thalassemia, sickle cell disease, spherocytosis) and Hodgkin's disease. 23 elements (Na, Al, Cl, Ca, Sc, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Se, Br, Rb, Ag, Sb, Cs, Ba, Au, Hg, Pb) have been detected in serum. Their relative concentration variations correlated with the nature of the disease and with other pathological alterations of blood are discussed.

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Abstract  

The method of proton-induced X-ray emission (or PIXE) analysis has been investigated with reference to the study of minor and trace elements in biological tissue. Methods of specimen preparation have been investigated, and optimum instrumental conditions arrived at. The lower limits of detection for lead and zinc in blood have been investigated and have been found to be approximately 0.3 and 0.1 ppm for lead and zinc respectively, for a proton energy of 2.5 MeV. The concentrations of copper, zinc and iron have been studied in normal and diseased human liver tissue. In cirrhotic tissue the copper levels are substantially raised. We note also a diminution in liver iron in a case of alcoholic cirrhosis associated with clinical anaemia; and a blood zinc deficiency in primary biliary cirrhosis. The results are discussed in relation to existing work.

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Abstract  

Ferrous gluconate Fe(C6H11O7)2·2H2O was investigated by means of57Fe (14.4 keV)-Mössbauer spectroscopy and thermogravimetry. The Mössbauer study was performed in the temperature range 80 to 423 K. It was found that Fe2+ occupies two distinctly different Mössbauer sites in the hydrated phase and a single site in the product of the thermal treatment. All samples were contaminated by some amount of Fe3+. A significant oxidation occurs during thermal treatment (about 378 K) at least for the samples exposed to the air. No Goldanskii-Karyagin effect has been detected, in contrast to the previous claim. It has to be noted that the ferrous gluconate is often used as the iron containing component of drugs used in the treatment of anaemia.

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Journal of Radioanalytical and Nuclear Chemistry
Authors: M. Durosinmi, J. Ojo, A. Oluwole, O. Akanle, W. Arshed, and N. Spyrou

Abstract  

Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-ray Emission (PIXE) analysis (employed as a complementary technique) have been used to determine the concentration of 11 elements in blood samples and its components erythrocytes and plasma obtained, from three groups of subjects in Nigeria viz: sickle cell anaemia (SCA) subjects, subjects with sickle cell trait and normal control subjects. The results suggest that SCA subjects have significantly higher concentrations of Na, Cl, Ca and Cu in their whole blood and erythrocytes and a higher concentration, of Cl and Cu in their plasma relative to the control subjects. Furthermore, a significantly lower concentration of K, Fe, Zn, Se, Br and Rb were found in the whole blood and erythrocytes of the SCA subjects as compared to the controls while the concentration of K and Fe in the plasma of the SCA subjects were however, found to be significantly higher than that of the control group. The study also shows that there was no significant differences between the concentration of these 11 elements in the group with sickle cell trait and the normal control group.

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being consumed by diabetics and also for controlling the anaemia, the tiredness conditions and for the mineralizing effect. The polysaccharides in fruit body and mycelium contain β-glucan, with antioxidant, anti-cholesterol, anti-viral and

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diabetes, high blood pressure, skin disease, anemia, scurvy, obesity, arthritis, and other diseases [ 7 – 13 ]. The nutritive value and medicinal value of Moringa are getting more and more attention [ 14 ]. Medicinal plants have diversified types

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.g., anemia, hypertension, depression, osteoporosis) [ 2 ]. Nowadays, epidemiological and experimental studies have shown many positive effects of regular coffee intake on neurological conditions, psychoactive responses, and metabolic disorders, as well as

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consumed in a year by humans from the produced 77 million t protein ( Steinfeld et al., 2006 ). Utilizing of animal blood in high volume may be a solution for iron deficiency anemia, which affects 1.6 billion people (in Africa 64.6%, in Asia 47.7%, in

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, which may take place both in water and in human digestive system. Nitrites pose a direct threat to health causing methemoglobinemia, hypertension, anaemia, inhibition of body mass growth or formation of carcinogen nitrosamines in the alimentary tract

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