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30 131 Covert, S. F.: Supernumerary chromosomes of filamentous fungi. Curr Genet 33 , 311 (1998). Supernumerary chromosomes of

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Malathion is an organophosphate insecticide that has been widely used for both domestic and commercial agricultural purposes. However, malathion has the potential to produce toxic effects in mammalian systems. In this study, Pseudomonas aeruginosa AA112 which was isolated from soil using enrichment technique could utilize the malathion as a sole carbon source and a source of energy. Pseudomonas aeruginosa AA112 was able to grow in MSMPY medium containing 42.75 mg/ml malathion. However, the optimum concentration of malathion which supported the maximum bacterial growth was found to be 22. 8 mg/ml. Malathion was used as an initial source of energy and carbon when it was found without additional carbon sources (in MSM medium) while it was utilized as second source of energy and carbon in a nutrient-supplemented medium (in MSMPY medium). Moreover, lead acetate test indicated that malathion was first attacked at a sulphur site 1–2 hours after the start of incubation. TLC and IR analysis indicated that malathion was completely degraded into diethyl succinate, hydrogen sulphide and phosphates. Therefore a malathion degradation pathway was proporsed. The degradation of malathion is attributed to the genes located on the chromosome and at least three proteins of high molecular size might be involved in malathion utilization. Bacteria able to use malathion as a food source or metabolize its residues in the environment to inactive, less toxic, and harmless compounds, could be used in bioremediation of an environmental pollution caused by the pesticide.

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Abe, S., Miyake, Y. I., Kageyama, S. I., Watanabe, G., Taya, K. and Kawakura, K. (1999): Deletion of the Sry region on the Y chromosome detected in case of equine gonadal hypoplasia (XY female) with abnormal

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Hungarian Medical Journal
Authors: László Ságodi, Enikő Sólyom, András Tóth, Anna Kékesi, Erika P. Tardy, Éva Borbás, Teofil Rétfalvi, Ákos Kiss and Anikó Korcsmáros

Aktas, D., Alikasifoglu, M., Gonc, N. et al.: Isodicentric Y (p11.32) chromosome in an infant with mixed gonadal dysgenesis. Eur. J. Med. Genet., 2006, 49 , 141

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Orvosi Hetilap
Authors: László Ságodi, Enikő Sólyom, András Tóth, Anna Kékesi, Erika P. Tardy, Éva Borbás, Teofil Rétfalvi, Ákos Kiss and Anikó Korcsmáros

Aktas, D., Alikasifoglu, M., Gonc, N. és mtsai: Isodicentric Y (p11.32) chromosome in an infant with mixed gonadal dysgenesis. Eur. J. Med. Genet., 2006, 49 , 141

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Breen, M., Langford, C. F., Carter, N. P., Fischer, P. E., Marti, E., Gerstenberg, C., Allen, W. R., Lear, T. L. and Binns, M. M. (1997): Detection of equine X chromosome abnormalities in equids using a horse X

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Orvosi Hetilap
Authors: Gabriella P. Szabó, Beáta Bessenyei, Erzsébet Balogh, Anikó Ujfalusi, Katalin Szakszon and Éva Oláh

Flint, J., Wilkie, A. O., Buckle, V. J. és mtsai: The detection of subtelomeric chromosomal rearrangements in idiopathic mental retardation. Nat. Genet., 1995, 9 , 132–140. Buckle V. J

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Hematológia–Transzfuziológia
Authors: András Kozma, Melinda Paksi, Emma Ádám, András Bors, Hajnalka Andrikovics and Gábor Mikala

. Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion. Oncogene 2013; 32: 1110–1120. 16 Wei S, Chen X

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Blaschke, R. J. and Rappold, G. A. (1997): Man to mouse — lessons learned from the distal end of the human X chromosome. Genome Res. 7, 1114–1117. Rappold G. A

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