Authors:Alica Letnická, Viera Karaffová, Mikuláš Levkut, Viera Revajová and Róbert Herich
Campylobacteriosis is mainly caused by infection with Campylobacter jejuni following consumption or handling of Campylobacter-contaminated poultry meat. The aim of this study was to investigate the effect of probiotic Enterococcus faecium AL41 on TGF-β4 and IL-17 expression and on immunocompetent cell distribution after C. jejuni infection in broiler chicken, as a second part of the previous study of Karaffová et al. (2017). Accordingly, day-old chicks were randomly divided into four experimental groups of 10 chicks each (n = 10): control (C), E. faecium AL41 (EFAL41), C. jejuni CCM6191 (CJ), and combined E. faecium AL41 + C. jejuni CCM6191 (EFAL41 + CJ). Samples from the caecum were collected on days 4 and 7 post Campylobacter infection (dpi), for the isolation of mRNA of TGF-β4, IL-17 and for immunohistochemistry. The relative mRNA expression of TGF-β4 was upregulated in the combined (EFAL41 + CJ) group compared to other groups during both samplings, but the expression of IL-17 was downregulated. Similarly, the highest density of CD3+ was detected in the combined group at 7 dpi, but the number of IgA+ cells was increased in both groups with EFAL41. It was concluded that the EFAL41 probiotic E. faecium strain can modulate the expression of selected cytokines (upregulation of TGF-β4 but downregulation of IL-17 relative expression), and activate IgA-producing cells in the caeca of chicks infected with C. jejuni CCM6191.
The role of enteropathogenic infection, localimmunity, and autosensibilisation in pathogenesis of acute surgical diseases of peritoneal cavity by the example of acute appendicitis. Klin. Khir., 2004,
Authors:Olivér Rosero, Tibor Kovács, Péter Ónody, László Harsányi and Attila Szijártó
., Laissue, J. A.: Bacterial translocation in the normal human appendix parallels the development of the localimmune system. Ann. N.Y. Acad. Sci., 2004, 1029 , 337–343.
Takesue, Y., Ohge, H., Uemura, K., et al
Authors:Mona Abdel Fattah Razin, Ahmed Osman, Mohamed Ahmed Ali, Mahmoud Mohamed Bahgat and Amany Sayed Maghraby
of the IMI to induce localimmune responses in the draining lymph node unlike the uneasy stimulation of the distal lymphoid organs in case of IPI which is always accompanied by systemic dilution of the antigens.
Authors:Natalya V. Permyakova, Pavel A. Belavin, Dariya S. Pirozhkova, Elena G. Ufimtseva, Sergey M. Rozov, Sergey R. Mursalimov, Yuriy V. Sidorchuk, Elena A. Uvarova, Alla A. Zagorskaya, Tatiana V. Marenkova, Svetlana V. Bannikova, Evgeniy A. Demidov, Konstantin V. Starostin, Marionella A. Kravchenko, Diana V. Vakhrusheva, Roman B. Berdnikov, Natalya I. Eremeeva, Sergey N. Skornyakov, Sergey E. Peltek and Elena V. Deineko
Samten , B.
Shams , H.
: Vaccination strategies to enhance localimmunity and protection against Mycobacterium tuberculosis . Vaccine 27 , 1816 – 1824 ( 2009 ). Available at http