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polymerization of propylene using heterogeneous multi-site Ziegler–Natta catalyst and find the best estimate of kinetic parameters using numerical solution of kinetic model combined with the Nelder–Mead simplex method as an optimization algorithm [ 3 , 34 , 35

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The international healthcare systems interoperability is an unresolved technological area at the moment. This paper demonstrates the results of the software engineering research for simplex syntactic and semantic technical interoperability of hospital information systems, eHealth smart device technology and clinical telemedicine instruments through the recently developed Telemedicine Interoperability Hub. Several similar experiments exist. This research is unique in building a prototype interconnecting not only healthcare information systems with each other, but aiming to establish a general healthcare interoperability scheme including also the eHealth smart devices and telemedicine instruments. The aim of this research is to establish cloud-based data interchange capability with the newly developed information technology system interconnected with the emerging eHealth Internet of Things solutions and the classical hospital information system architecture. Notwithstanding the international information technology medical data exchange standards, like Health Level Seven, the adoption of an industry-wide open telemedicine syntactic and semantic interoperability standard is necessary. The research studied varying simplex, duplex, full-duplex, data package- and file-based information technology modalities establishing stable system interconnection among clinical instruments, healthcare systems and eHealth smart devices. This research is the manifestation of the trilateral cooperation of the University of Debrecen Department of Information Technology, Semmelweis University Second Paediatric Clinic and T-Systems Healthcare Competence Center Central and Eastern Europe. The developed experimental software engineering solution was embedded in hybrid cloud architecture after testing private cloud Infrastructure-as-a-Service and Public Cloud Software-as-a-Service technical solutions.

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The objective of this study was to examine antibacterial, antifungal and antiviral properties of selected Phlomis species (Lamiaceae) growing in Turkey. The petroleum ether and methanol extracts of the seven species, namely P. armeniaca Willd., P. bourgaei Boiss., P. leucophracta P.H. Davis & Hub.-Mor., P. lunariifolia Sibth. & Sm., P. lycia D. Don, P. pungens Willd. var. pungens , and P. pungens var. hirta Velen. were tested against Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Bacillus subtilis , and Enterococcus faecalis for their antibacterial activity using ampicillin and oflaxocin as references. Antifungal activity of the same extracts was determined against Candida albicans using microdilution method with ketocanazole as reference. Both DNA virus Herpes simplex type-1 (HSV-1) and RNA virus Parainfluenza (PI-3) were employed for antiviral assessment of the Phlomis extracts using Madin-Darby Bovine Kidney and Vero cell lines in which acyclovir for HSV-1 and oseltamivir for PI-3 were employed as reference drugs. Although both the petroleum ether and methanol extracts seemed to exert similar antibacterial activity, the methanolic extracts were observed to be more active against S. aureus and E. faecalis . On the other hand, methanolic extract of P. pungens var. pungens possessed notable antiviral activity against both type of viruses.

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Acta Alimentaria
Authors: L. Silva, G. Maia, P. Sousa, R. Figueiredo, M. Afonso, M. Gonzaga, C. Gomes and E. Figueiredo

The purpose of this experiment was to evaluate the effect of heat treatment on the rheological properties of mixed nectars, based on cashew apple, mango, and acerola pulps. Ten different formulations with different mass fractions of cashew apple, mango, and acerola pulps were prepared using a simplex centroid design [with a total of 35% (w/w) pulp] and submitted to heat treatment at 90 °C for 1 min. Samples were collected before and after heat treatment and characterization of their rheological properties was carried out. The rheological behaviour was obtained at 25 °C, with shear rate ranging from 108 to 500 s−1 (upward curve) and from 500 to 108 s−1 (downward curve) for 1 min with 25 readings for each curve. The Ostwald de Waele model showed to be a good fit for all formulations studied, which showed a non-Newtonian behaviour and a pseudoplastic character. Results of apparent viscosity for the non-heated formulations were well fitted by the linear model and the heat treated formulations by the cubic model. The heat treated formulations had higher (P<0.05) values of consistency index and apparent viscosity, as well as lower (P<0.05) values of flow behaviour index compared to non-heated formulations. The rheological characterization of these formulations is a very useful tool during product development and processing control of mixed nectars of fruit juice.

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A zero-one linear program is a global discrete optimization problem. Namely, it is a linear programming problem with zero-one variables. The real relaxation of a zero-one program is again a continuous linear programming problem. Simply, the zero-one variables are replaced by continuous variables varying between zero and one independently of each other. If the real relaxation, as a continuous problem, solved with the simplex method happens to have a zero-one optimal solution, then this particular solution is also an optimal solution of the original zero-one programming problem. Suppose that x 1,…,x n are all the variables of a given zero-one linear programming problem. For convenience we introduce further variables y 1,…,y n defined by y 1=1−x 1,…, y n=1−x n respectively. For a unified notation the variables x 1,…,x n and y 1,…, y n together will be denoted by z 1,…,z 2n. These variables will play the roles the nodes of the conflict graph Г associated with the given zero-one linear programming problem. Fixing the variables z i and z j both to be equal to one simultaneously reduces the number of variables in the problem. If the new smaller optimization problem does not have any feasible solution, then the nodes z i and z j will be connected by an edge in the graph Γ. The graph Γ simply records that there is a conflict between the assignments z i =1 and z j =1 which explains the name conflict graph. In other words the non-directed edge between the nodes z i and z j codes the fact that the inequality z i+z j≤1holds. The conflict graph was designed to generate additional constraints the so-called valid inequalities or cuts in order to expedite the solution of the zero-one linear program via its real relaxation. This particular solution strategy is aptly named the branch and cut method. It will be shown that the conflict graph besides its intended use can also be applied in another solution technique the method of implicit enumeration. We will illustrate by examples that the conflict graph provides us with rules to prune the search tree that are not offered by the commonly applied pruning rules. In addition the computations involved can easily be organized into a highly parallel computational scheme.

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. 287–336. Nelder J. A., Mead R. A simplex method for function minimization, Comput. J. , 7, 1965, pp. 308–313. Mead R. A simplex method for

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and its properties , JSAEM Studies in Applied Electromagnetics, Vol. I, Oita, Japan, 1992. Lagarias J., Reeds J. A., Wright M. H., Wright P. E. Convergence properties of the Nelder-Mead simplex method in low

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Acta Alimentaria
Authors: A. Csikos, A. Hodzic, E. Pasic-Juhas, A. Javor, A. Hrković-Porobija, T. Goletic, G. Gulyas and L. Czegledi

ATTA , T.K. & G OSWAMI , S.L. ( 2011 ): Simplex and duplex PCR assays for species specific identification of cattle and buffalo milk and cheese . Food Control , 22 , 690 – 696

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A. , Toufigh M. M. Application of Nelder-Mead simplex method for unconfined seepage problems , Applied Mathematical Modeling , Vol. 33 , No. 9 , 2009 , pp. 3589 – 3598 . [25

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account. Eq. 12 is the analytical solution of the separable first order ordinary differential equation (ODE) represented by Eq. 9 . The simplex method of optimization [ 30 ] was applied to tune simultaneously the entire set of model

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