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Authors: Donata Grimm, Linn Woelber, Katharina Prieske, Barbara Schmalfeldt, Sascha Kürti, Chia-Jung Busch, Ingo Teudt, Oliver Brummer, Volkmar Mueller and Thomas Meyer

A subgroup of oropharyngeal squamous cell carcinomas (OSCCs) are causally linked to infection with high-risk human papillomaviruses (HR-HPVs). To evaluate the prevalence of simultaneous oral HPV infection in females with cervical high-grade squamous intraepithelial lesions (HSIL), tonsillar- and cervical smears were collected simultaneously from 73 patients and analyzed for HPV using two commercial assays, PapilloCheck (Greiner-Bio-One) and Linear Array (Roche). Only 3/73 (4.1%) tonsillar smears were HPV positive (HPV+), with HPV types 16, 35, and 45, respectively, detected by both assays (100% agreement). Concordant results were also found in 60/66 (91%) evaluable cervical smears. Of specimens, positive by both assays, typing results completely coincide in 71% (all types are identical) and partially coincide in 27% (at least one type is identical). Taken together, results of HPV detection and typing by PapilloCheck and Linear Array are highly congruent and confirm the low prevalence of HR-HPV in tonsillar smears of patients with HSIL of the uterine cervix. Our data indicate low prevalence of oropharyngeal HPV infection in patients with high-grade cervical dysplasia. The low detection rate was confirmed by using two different commercial assays with largely consistent results of HPV detection and typing, but with some variation for particular HPV types. Comparative testing of larger numbers is required to identify the HPV types prone to escape detection with particular assays.

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., Mezzetti, M., Testolin, A., Bevilacqua, P. (1993) Intratumoral microvessel density and p53 protein: correlation with metastasis in head and neck squamous-cell carcinoma. Int. J. Cancer 55:5 , 739-744. Intratumoral microvessel

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Authors: Tamara Babic, Jelena Dinic, Sonja Stojkovic Buric, Stefan Hadzic, Milica Pesic, Dragica Radojkovic and Aleksandra Divac Rankov

Cell Carcinoma by Inhibiting AKT/mTOR Axis and Inducing G1/ G2/M Cell Cycle Arrest . PLoS One . 11 , e0151942 .

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Authors: A. Mádi, Tünde Pusztahelyi, Mária Punyiczki and L. Fésüs

bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. Cancer Res. 57 , 4111-4117. Proteome profiling of bladder squamous cell carcinomas: identification of markers that define

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Authors: P. Vidyasagar, V. Nimmagadda Sridevi PhD, S. Rajan, A. Praveen, A. Srikanth, G. Abhinay, V. Siva Kumar, R. R. Verma and L. Rajendra

detection in cervical squamous cell carcinoma Clin Cancer Res 13 7067 7072 .

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, A. ( 2014 ) RAS/PI3K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma . Clin. Cancer. Res. 20 , 2933 – 2946 . Rihova , B

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Authors: A. Ansari Pour, S. Tirgari, J. Shakarami, S. Imani and A. F. Dousti

. R. and Fallahzadeh, M. K. (2009): Wound myiasis in a patient with squamous cell carcinoma. Sci. World J. 1, 1192–1193. 61 Nandi, B. C. (2002

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