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Abstract  

The radionuclide vanadium-48 (T 1/2 = 16 d, β += 49.5 %) could be employed to positron emission tomography. In this Study, 48V excitation function for the nat/49/48Ti(p,x)48V and the 48Ti(d,2n)48V nuclear reactions were calculated by ALICE/ASH code. Then recommended thickness of the targets according to the SRIM-2010 code was calculated; consequently, the theoretical integral yields were computed for all reactions by the computer software. As a result, the 48Ti(p,n)48V reaction was determined as the best reaction. Ti target was prepared by sedimentation method to produce 48V throughout accelerator proton bombardment.

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Abstract  

The Nitinol stent was bombarded in a cyclotron at a flux rate of 4 μA/cm2 to produce 48V via 48Ti (p, n) 48V reaction. In this study dose distribution of 48V radioactive stent was investigated for renal arteries. Version X-2.6 of the MCNP Monte Carlo radiation transport system code was employed to calculate dose distribution around the stent. As 48V is a mixed gamma and beta particle emitter, two separate runs of MCNP for both beta and gamma particles were performed and the total deposited dose was acquired by adding the two mentioned values. In order to verify the simulation, the calculated results have been compared with previous published data for the source. Calculated results show high dose gradient near the stent and the maximum amount of dose deposits at the vessel wall. According to (AAPM) TG-60/149 protocol, the dosimetric parameters, including geometry function, G(ρ,z), radial dose function, g L(ρ), and anisotropy function, F(ρ,z), were also determined.

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