Authors:Reza Ranjbar, Masomeh Bolandian, and Payam Behzadi
mortality among pediatric populations worldwide and in particular developing countries. The infection of shigellosis is caused by non-motile, facultative anaerobic Gram-negative coccobacilli of Shigella spp. Shigella spp. are categorized into four
Shigellosis or bacillary dysentery caused by four Shigella species ( Shigella flexneri, Shigella dysenteriae, Shigella boydii , and Shigella sonnei ) is known as a main public health problem worldwide especially
Authors:Fatema Moni Chowdhury, Mohammed Ziaur Rahman, Md Murshed Hasan Sarkar, Fazle Rabbi, Sirajul Islam Khan, Chowdhury Rafiqul Ahsan, and Nils-Kåre Birkeland
Shigella species (spp.) are the causative agents of acute diarrheal disease, shigellosis, with symptoms including abdominal cramps, watery or bloody diarrhea, and fever. Recent estimates represent
Authors:Fatima Bachir Halimeh, Rayane Rafei, Seydina Diene, Mary Mikhael, Hassan Mallat, Marcel Achkar, Fouad Dabboussi, Monzer Hamze, and Jean-Marc Rolain
widespread occurrence [ 3, 4 ]. Diarrheal diseases are caused by a variety of etiological agents (viral, parasitic, and bacterial). Among bacterial etiological agents, Escherichia coli and Shigella spp. are two of the most common cause of bacterial
Authors:Fatema Moni Chowdhury, Chowdhury Rafiqul Ahsan, and Nils-Kåre Birkeland
Introduction Shigellosis, a severe, intensely inflammatory gastrointestinal disease caused by Shigella dysenteriae is an important cause of morbidity and mortality not only in developing countries, but also in the developed countries. In the
In this study, the microcalorimetric method was applied to investigate the activity of berberine on Shigella dysenteriae (S. dysenteriae). Heat flow power (HFP)–time curves of the growth metabolism of S. dysenteriae affected by berberine were determined using the thermal activity monitor (TAM) air isothermal microcalorimeter, ampoule mode,
at 37 °C. By analyzing these curves and some quantitative parameters using multivariate analytical methods, similarity analysis
(SA) and principal component analysis (PCA), the antibacterial activity of berberine on S. dysenteriae could be accurately evaluated from the change of the two main parameters, the maximum heat flow power Pm2 and total heat output Qt: berberine at low concentration (25 μg mL−1) began to inhibit the growth of S. dysenteriae, high concentrations (50–200 μg mL−1) of berberine had strong antibacterial activity on S. dysenteriae, when the concentration of berberine was higher (250–300 μg mL−1), this antibacterial activity was stronger. All these illustrated that the antibacterial activity of berberine on S. dysenteriae was enhanced with the increase of the concentration of this compound. Berberine can be used as potential novel antibacterial
agent for treating multidrug-resistant Shigella. This work provided a useful idea of the combination of microcalorimetry and multivariate analysis for studying the activity
of other compounds or drugs on organisms.
Authors:K. Baintner, B. Kocsis, Krisztina Kovács, Z. Péterfi, G. Kökény, and P. Hamar
′-diphosphate-L-glycero-D-mannoheptose, the assumed substrate of heptose transferase(s), from Salmonella minnesota R595 and Shigella sonnei Re mutants. J. Biol. Chem. 259 , 11858–11860 (1984).