Search Results
Abstract
A microcalorimetric technique based on the bacterial heat output was applied to evaluate the influence of antibiotics PIP (Piperacillin Sodium) and composite preparation of PIP and SBT (Sulbactam Sodium) on the growth of E. coli DH5α. The power–time curves of the growth metabolism of E. coli DH5α were studied using a TAM Air Isothermal Microcalorimeter at 37C. By analyzing the power–time curves, the parameters such as growth rate constants (k), inhibitory ratio (I), the maximum heat power (P m) and the time of the maximum heat power (t m) were obtained. The results show that different concentrations of antibiotics affect the growth metabolism of E. coli DH5α. The PIP in the concentration range of 0–0.05 g mL–1 has a stimulatory effect on the E. coli DH5α growth, while the PIP of higher concentrations (0.05 –0.25 g mL–1) can inhibit its growth. It seems that the composite preparation composed of PIP and SBT cannot improve the inhibitory effect on E. coli DH5α as compared with the PIP.
the CR-ROR strain, the patient had used antibacterial drugs like amikacin, levofloxacin, and imipenem. After CR-ROR isolation, cefoperazone/sulbactam sodium was used. The patient was in a coma after discharge, and given up treatment. WF2441 was
. 18. Mai , X. L. ; Pham , T. V. ; Han , G. H. ; Kum , S. J. ; Woo , S. H. ; Kang , J. S. ; Woo , M. H. ; Na , D. H. ; Chun , I. K. ; Kim , K. H. Simultaneous determination of ampicillin sodium and sulbactam sodium in powder for
