Search Results

You are looking at 1 - 2 of 2 items for :

  • "4-methylpyrazole" x
  • Refine by Access: All Content x
Clear All
Acta Physiologica Hungarica
Authors:
J Dudka
,
F Burda
,
Barbara Madej
,
Justyna Szumilo
,
Edyta Tokarska
,
Agnieszka Korobowicz
,
R Klepacz
,
Monika ChyüyÅska
, and
Elżbieta Korobowicz

Metabolic acidosis complicates methanol, ethylene glycol and other alcohol intoxications. It is caused firstly by acid metabolites and secondly by the lactate elevation. The aim of the study was to evaluate the effect of alcohol dehydrogenase (ADH; EC 1.1.1.1) inhibitors and substrates: 4-methylpyrazole (4-MP), cimetidine, EDTA, ethanol and methanol on lactate dehydrogenase (LDH; EC 1.1.1.27) activity. The activity of LDH was determined spectrophotometrically in in vitro human heart homogenates with the mentioned compounds at 0.01, 0.1, 1.0 mM concentrations of 4-MP, cimetidine, EDTA, and 12.5, 25.0, 50.0 mM of ethanol and methanol. The LDH activity was significantly inhibited by 0.1 mM (p<0.05) and 1.0 mM (p<0.01) 4-MP and 1.00 mM EDTA (p<0.05). Higher LDH activity vs. control was observed in the samples incubated with all studied ethanol and methanol concentrations but these differences were not statistically significant. Thus, 4-MP was found to be the most effective inhibitor of LDH of all compounds tested. Therefore, such effect of 4-MP seems to be an additional advantage in methanol and ethylene glycol intoxications.

Restricted access

New palladium(II) complexes with pyrazole ligands

Part II. Synthesis, spectral and thermal studies, and antitumor evaluation

Journal of Thermal Analysis and Calorimetry
Authors:
Carolina V. Barra
,
Fillipe V. Rocha
,
Adelino V. G. Netto
,
Regina C. G. Frem
,
Antonio E. Mauro
,
Iracilda Z. Carlos
,
Sandra R. Ananias
, and
Marcela B. Quilles

studies on the compounds [PdCl 2 (HmPz) 2 ] 1 , [PdBr 2 (HmPz) 2 ] 2 , [PdI 2 (HmPz) 2 ] 3 , [Pd(SCN) 2 (HmPz) 2 ] 4 {HmPz = 4-methylpyrazole}. The cytotoxic activities of the complexes and the ligand were investigated against two murine cancer cell

Restricted access