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Ottaviani, E., Franchini, A., Genedani, S.: ACTH and its role in immune-neuroendocrine functions. A comparative study. Curr Pharm Des 5 , 673–681 (1999). Genedani S. ACTH and its role in

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Orvosi Hetilap
Authors: Attila Szabó, Péter Igaz, Róbert Kiss, Gergely Lakatos, Ibolya Varga, and Károly Rácz

ectopic ACTH syncdrome. Clin. Endocrinol., 1992, 37 , 483–392. Fraser R. Mineralocorticoid excess and inhibition of 11-beta-hydroxysteroid dehydrogenase in patients with ectopic ACTH

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[11, 12] . The presence of intracellular LH-like factor [13] , growth hormone releasing hormone [14] , thyrotropic hormone and triiodothyronine (T3) [15] , adrenocorticotropic hormone (ACTH) [16] , endorphin [17, 18] , human chorionic gonadotropin

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The aim of this study was to investigate the effects of ACTH, phytoestrogens (genistein, daidzein, biochanin A and coumestrol), and animal estrogens (estradiol and estrone) on corticosterone secretion by isolated adrenocortical cells of the ganders in breeding (April) and nonbreeding seasons (July). ACTH stimulated corticosterone output in the breeding season. In July (photorefractoriness and postbreeding molt) ACTH had no effect on corticosterone production. Coumestrol reduced corticosterone secretion by the cells obtained in nonbreeding season. Other examined phytoestrogens did not affect corticosterone production. Estrogens showed differentiated effects. Estradiol stimulated the corticosterone output in breeding season; estrone inhibited corticosterone release in July. The season can probably affect sensitivity of isolated gander adrenal cells, especially to ACTH. It seems that goose adrenocortical cells, in contrast to the mammalian cells, can be weakly sensitive to phytoestrogens.

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Orvosi Hetilap
Authors: Miklós Tóth, Zsolt Vajda, Zoltán Görömbey, Ferenc Molnár, László Major, Judit Tőke, István Szabolcs, Nikolette Szücs, László Kovács, Róbert Kiss, Sándor Czirják, László Fütő, Edit Gláz, Miklós Góth, and Károly Rácz

A hipofízis adrenokortikotropin-termelő adenomája okozta Cushing-kór és az ectopiás Cushing-szindróma elkülönítése a hagyományos hormonvizsgálatok és a képalkotó vizsgálatok segítségével nem mindig lehetséges. A két betegség elkülönítésének aranystandardja napjainkban a sinus petrosus inferiorok szelektív katéterezése (IPSS) során nyert vérmintákból történő ACTH-meghatározás. A szerzők 1999 és 2005 között 34 Cushing-szindrómás betegen összesen 41 alkalommal végeztek IPSS-t, akiknél a dinamikus hormonvizsgálatok és a képalkotó vizsgálatok alapján az ACTH-dependens Cushing-szindróma okát nem lehetett egyértelműen megállapítani. A beavatkozás szenzitivitásának meghatározásakor 25 beteg 31 vizsgálatának eredményét értékelték, akiknél a végleges diagnózist sikeres műtéti beavatkozás vagy szövettani vizsgálat erősítette meg (22 ACTH-termelő hipofízisadenoma, 3 ectopiás Cushing-szindróma). Az IPSS eredményét pozitívnak tekintették, ha a kiindulási centrális/perifériás plazma-ACTH-hányados >2,0, vagy kortikotrop releasing hormon (CRH) adása után >3,0 volt. A 31 vizsgálat eredménye 20 esetben valódi pozitív, 3 esetben valódi negatív, 8 esetben álnegatív volt, álpozitív eset nem fordult elő. Az eredmények alapján az IPSS szenzitivitása 71,4%. Az ál-negatív 8 beteg közül 4 esetben a vizsgálatot megismételték, mind a négy betegben pozitív eredménnyel. Cushing-kórban a 20 valódi pozitív vizsgálat közül 14 esetben a diagnózis a 0 perces ACTH-szintek alapján is megállapítható volt, a CRH utáni 5 perces vérminták alapján 19 betegnél lehetett a Cushing-kór diagnózisát megállapítani. Az IPSS vizsgálat itt bemutatott első hazai feldolgozásában a módszer szenzitivitása alacsonyabb, mint a jóval nagyobb betegforgalmú külföldi endokrin centrumokban. A kisebb szenzitivitás technikai okokon túlmenően azzal is magyarázható, hogy a szerzők az IPSS-t csak szigorúan válogatott esetekben, az egyéb vizsgálatokkal nem egyértelműen kórismézhető betegeken végzik.

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The aim of the present study was to evaluate the relationship between corticosterone, body weight, insulin and androstenedione in order to understand the role of adrenal in contributing hyperandrogenism during delayed ovulation in S. heathi. The circulating corticosterone concentration in female S. heathi showed significant seasonal variation. The peak corticosterone concentration observed during August-September coincides with increased feeding activities in S. heathi. The present study noted a seasonal variation in relationship of corticosterone with insulin and androstenedione in S. heathi. An inverse relationship of corticosterone with insulin and androstenedione was found during August to December, but not during January to May. A seasonal variation in the effect of adrenocorticotropic hormone (ACTH) on adrenal corticosterone production in vitro was observed during reproductive cycle. Corticosterone production in vitro by adrenal declined significantly as compared to the control during quiescence in September. The finding suggests that adrenal attained the peak responsiveness to ACTH during September. ACTH significantly enhanced the androstenedione production by the adrenal in vitro during December, when the circulating androstenedione was also high in S. heathi. This suggests that the adrenal may also contribute to hyperandrogenism during the period of delayed ovulation in S. heathi. Further studies are required to reveal the unique pattern of seasonal relationship between corticosterone, insulin and androstenedione in S. heathi.

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Adrenocorticotropic hormone (ACTH), endorphin, progesterone and triiodothyronine (T 3 ) content of immune cells (lymphocytes, monocyte-macrophage-granulocyte group and mast cells of peritoneal fluid, blood lymphocytes and thymic lymphocytes) was studied by immunocytochemistry and flow cytometric analysis and compared in young (four weeks old) and sexually matured (two and a half months old) male and female rats. In most of cases, cells of female animals contained significantly more hormones, however, in the young group ACTH content of blood lymphocytes was double in males than that of females. In adults only T3 content of mast cells was higher in males. Progesterone was present only in the cells of the young group. The results show that i) hormone content in the immune cells is gender-dependent with the adventage of females and ii) this difference is not influenced by the sexual maturation.

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: Venepuncture causes rapid rise in plasma ACTH. Br. J. Clin. Pract. 47, 246–247 (1993) Bloom S.R. Venepuncture causes rapid rise in plasma ACTH Br. J. Clin. Pract

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6184 6186 LeRoith, D., Liotta, A. H., Roth, J., Schiloach, J., Lewis, M. E., Pert, C. B., Krieger, D. T.: ACTH and beta endorphin like materials are native to unicellular

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Adrenocorticotropic hormone (ACTH) and insulin inhibited the phagocytic activity of Tetrahymena . [ 39 ]. In addition, insulin antagonized the phagocytosis increasing action of histamine in T . pyriformis [ 40 ]. Arginine vasopressin decreased the phagocytic

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