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A simple, cost-effective, precise, accurate, and rapid planar chromatographic method was developed and validated for the separation and determination of amodiaquine and artesunate in tablet formulations. Both compounds were determined using high-performance thin-layer chromatography plates and a mobile phase composed of toluene, acetonitrile, methanol, ammonium acetate, and triethylamine in the ratio 10:5:3:1:0.5 (% v/v). Amodiaquine was evaluated densitometrically at a detection wavelength of λ = 345 nm, whereas artesunate was determined fluorimetrically at λ = 503 nm. The method was linear in the concentration ranges of 0.093–0.280 μg spot−1 for artesunate and 0.250–1.250 μg spot−1 for amodiaquine, respectively.

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response, the detector produces a voltage which is proportional to the power output from the sample. Reagents Standard artesunate drug was provided by Guilin Pharmaceutical Corp. Ltd. (Guo yao zhun zi H19994073

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Summary

A highly sensitive and reproducible isocratic liquid chromatographic method has been developed for the analysis of artemisinin and its three commonly used derivatives (artesunate, dihydroartemisinin, and artemether). The method involves a precolumn derivatization reaction with 4-carboxyl-2,6-dinitrobenzene diazonium ion to produce azo adducts that are UV-active. The critical parameters for the derivatization such as temperature, reaction time, and reagent concentrations were studied and optimized. The chromatographic separations were carried out on a C-18 column with mobile phase consisting of acetonitrile-0.1% acetic acid (60:40) at a flow rate of 1 mL min−1. UV detection was set at 254 nm. Dynamic linear calibration range was obtained at concentrations of artemisinins ranging from 0.26 to 1.44 μg mL−1. The low limits of detections of artemisinin, artesunate, dihydroartemisinin, and artemether were found to be 0.091, 0.0125, 0.0489, and 0.0128 ng μL−1, respectively. The developed methods were precise (RSD <3%) and accurate (% error < 5%). The developed methods may find application in dosage form analysis and pharmacokinetic studies.

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. 25. Jiraungkoorskul , W. , Sahaphong , S. , Sobhon , P. , Riengrojpitak , S. , Kangwanrangsan , N. ( 2005 ) Effects of praziquantel and artesunate on the tegument of adult Schistosoma

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)–densitometry methods. The model process was applied earlier to formulations containing acetylsalicylic acid, acetaminophen, ibuprofen, and chlorpheniramine maleate [ 1 ]; mebendazole, diphenhydramine HCl, amodiaquine, and artesunate [ 2 ]; amodiaquine and diazepam [ 3

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analyzed product (32.4 mg caffeine, 162 mg aspirin, and 110 mg acetaminophen; see Figure 2 ), was taken from a previously published method for the analysis of artesunate pharmaceutical products [ 7 ]. Figure 2

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