Search Results

You are looking at 1 - 10 of 11 items for :

  • "BCG vaccine" x
  • Refine by Access: All Content x
Clear All

Thermogravimetry and vapor pressure moisture

Applications to determination of residual moisture in BCG vaccine

Journal of Thermal Analysis and Calorimetry
Authors: J May, A Del Grosso, N Etz, R Wheeler, and L Rey

Abstract  

Thermogravimetry (TG), thermogravimetry/mass spectrometry (TG/MS), and loss-on-drying methodology are used to provide residual moisture results for freeze-dried biological products regulated by the US Food and Drug Administration. Residual moisture specifications must be met in order to ensure freeze-dried biological product potency and stability throughout the licensed product's shelf life. TG, TG/MS, loss-on-drying and vapor pressure moisture measurements are compared for a BCG Vaccine. Comparisons are made between residual moisture data for the freeze-dried cake and vapor pressure moisture determinations in the space above the freeze-dried cake in the final container. Vapor pressure moisture precision data is presented for α-interferon and BCG vaccine. Impact of residual moisture and vapor pressure moisture upon product stability is presented.

Restricted access
Acta Microbiologica et Immunologica Hungarica
Authors: Joana Korablioviene, Mykolas Mauricas, Irena Dumalakiene, Saulius Caplinskas, Rita Viliene, Justinas Baleisis, Gintautas Vysniauskis, Joanna Chorostowska-Wynimko, Ginreta Magelinskiene, Pavel Korabliov, and Arunas Valiulis

]. However, the BCG vaccine is not fully effective due to different BCG strains, the prevalence of environmental mycobacteria, differing host genetics, nutritional factors, and the presence of co-infections such as helminths [ 3 ]. Further, there are two

Restricted access

. bovis BCG strain expressing the 30-kDa major secretory protein of MTB in the guinea pig model, and obtained better protection than the commercial BCG vaccine. The complementation of BCG strain with ESAT-6 protein from MTB also increased the protection

Restricted access
Acta Microbiologica et Immunologica Hungarica
Authors: Natalya V. Permyakova, Pavel A. Belavin, Dariya S. Pirozhkova, Elena G. Ufimtseva, Sergey M. Rozov, Sergey R. Mursalimov, Yuriy V. Sidorchuk, Elena A. Uvarova, Alla A. Zagorskaya, Tatiana V. Marenkova, Svetlana V. Bannikova, Evgeniy A. Demidov, Konstantin V. Starostin, Marionella A. Kravchenko, Diana V. Vakhrusheva, Roman B. Berdnikov, Natalya I. Eremeeva, Sergey N. Skornyakov, Sergey E. Peltek, and Elena V. Deineko

://academic.oup.com/cid/article/58/4/470/347668/Protection-by-BCG-Vaccine-Against-Tuberculosis-A 10.1093/cid/cit790 3. Kaufmann , S. H. E. : Tuberculosis vaccines: Time to think about the

Restricted access

TG/MS capillary interface

Applications to determination of residual moisture in BCG vaccine and other freeze-dried biological products

Journal of Thermal Analysis and Calorimetry
Authors: J. May, A. Del Grosso, R. Wheeler, and N. Etz

Abstract  

A TA Instruments Thermal Analysis System (TG) has been interfaced to the Hewlett Packard 5972 quadrupole mass spectrometer. An OSS-2 variable outlet splitter was plumbed between the TG and the mass spectrometer. This interface allows continuous monitoring of the ion intensities of mass peaksm/e=18 (water) andm/e=44 (carbon dioxide) used to elucidate the TG transitions attributable to residual moisture in freeze-dried biological products. Moisture specifications must be met in order to insure product stability throughout the approved shelf life. TG/MS results are discussed for BCG Vaccine, BCG Live (Intravesical) and U. S. Standard Antihemophilic Factor. Karl Fischer and TG/MS moisture results are compared.

Restricted access

Az új koronavírus okozta járvány első hullámának jellemzői és esetleges kapcsolata a tuberkulózis elleni oltottsággal

A summary of characteristics of the first wave of new type coronavirus epidemic and potential association with tuberculosis vaccination

Orvosi Hetilap
Authors: Blanka Emődy-Kiss, Ágnes Pataki, Gábor Deli, Sándor Papp, Mária Mátyus, and János Fent

-CoV-2? Front Immunol. 2020; 11: 970. 18 Moorlag SJ, Arts RJ, van Crevel R, et al. Non-specific effects of BCG vaccine on viral infections. Clin

Open access

): Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis . . Vaccine 25 , 6730 – 6743 . Hwang , S

Restricted access
Acta Microbiologica et Immunologica Hungarica
Authors: Marek Fol, Anna Głobińska, Paweł Stączek, Magdalena Kowalewicz-Kulbat, Magdalena Druszczyńska, Murty Madiraju, and Wiesława Rudnicka

255 Barreto, M.L., Pereira, S.M., Ferreira, A.A.: BCG vaccine: Efficacy and indications for vaccination and revaccination. J Pediatr 82 , S45–S54 (2006

Restricted access
Interventional Medicine and Applied Science
Authors: Olexandr Smiyan, Mykola Lyndin, Oksana Romaniuk, Vladyslav Sikora, Artem Piddubnyi, Alla Yurchenko, Anna Korobchanska, Iryna Tarasova, Natalia Hyryavenko, Kateryna Sikora, and Anatolii Romaniuk

, poliomyelitis, etc.) in the first days of life and requires monitoring of the immunological status of children [ 17 – 19 ]. Consequently, in case of immunodeficiency, the BCG vaccine strain becomes “paradoxic agent” of opportunistic infection, despite the high

Open access

Koronavírusvakcina-vademecum

Corona vaccine review

Orvosi Hetilap
Authors: Gábor Xantus, Balázs Rékassy, and László Závori

development. EbioMedicine (Lancet) 2020; 55: 102743. 44 Moorlag SJ, Arts RJ, van Crevel R, et al. Non-specific effects of BCG vaccine on viral infections. Clin Microbiol Infect

Open access