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The effects of Amoxicillin Sodium and Cefuroxime Sodium on the growth of E. coli DH5α were investigated by microcalorimetry. The metabolic power-time curves of E. coli DH5α growth were determined by using a TAM air isothermal microcalorimeter at 37�C. By evaluation of the obtained parameters, such as growth rate constants (k), inhibitory ratio (I), the maximum heat power (P m) and the time of the maximum heat power (t m), one found that the inhibitory activity of Amoxicillin Sodium vs. E. coli DH5α is enhanced with the increasing of the Amoxicillin Sodium concentration, and the Cefuroxime Sodium has a stimulatory effect on the E. coli DH5α growth when the concentration is about 1 μg mL−1. The IC50 for the Amoxicillin Sodium and the Cefuroxime Sodium are 1.6 and 2.0 μg mL−1, respectively, it implicates that the E. coli DH5α is more sensitive to Amoxicillin Sodium than Cefuroxime Sodium.

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a new drug having better solubility and stability, as compared with cefuroxime sodium, the thermal stability and decomposition kinetic characteristics of cefuroxime lysine have to be determined for its further application and development ( Fig. 1

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European Journal of Microbiology and Immunology
Authors: Abdelaziz Ed-Dra, Fouzia Rhazi Filali, Slimane Khayi, Said Oulghazi, Brahim Bouchrif, Abdellah El Allaoui, Bouchra Ouhmidou, and Mohieddine Moumni

Ceftriaxone CRO 30 µg Cefuroxime sodium CXM 30 µg Ceftazidime CAZ

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