Authors:Rodica Olar, Mihaela Badea, Dana Marinescu, Larisa Calu, and Cristina Bucur
Although many complexes showed a good antimicrobial or antiviral activity so far only a few are used as metalloantibiotics (antiseptics and antimicrobial) or metalloantiviral drugs [ 1 ]. Having in view the
Authors:Cristina Bucur, Mihaela Badea, Calu Larisa, Dana Marinescu, Maria Nicoleta Grecu, Nicolae Stanica, Mariana Carmen Chifiriuc, and Rodica Olar
compounds, the binuclear complexes with bis(azamacrocyclic) ligands are subject of extensive investigation concerning metal–metal interactions as well as structural and catalytic effects [ 1 , 2 ]. The presence of two metal centres within a small distance
Authors:Ana Maria Rocco, James L. Wardell, and Robson Pacheco Pereira
In the last two decades, there has been a great interest in metal complexes, organometallics and related molecular conductive systems due to the possibility of obtaining new materials with optimized properties for
The synthesis of complexes of metal ions with heterocycles ligands is currently subject of considerable interest, mainly as an approach to materials with novel physicochemical properties and biological activity
Authors:Murat Turkyilmaz, Alper Onder, and Yakup Baran
Azomethine metal complexes attract considerable interest and occupy an important role in the development of the chemistry of chelate systems because of the presence of hard nitrogen, oxygen, and soft sulfur donor
Authors:M. Gaber, G. B. El-Hefnawy, M. A. El-Borai, and N. F. Mohamed
Transition metal azo complexes have played an important role in the development of coordination chemistry [ 1 – 17 ] and have wide applications in industry and biological systems [ 18 – 20 ]. Azo-compounds based on
Authors:L. Fuks, E. Gniazdowska, P. Kozminski, and J. Mieczkowski
Technetium(I) tricarbonyl complexes may form with the pyridine aldehyde thiosemicarbazones (TSCs), in which chelating ligand
is bound tri- or bidentately. Intend of the presented work was to check, if labeling the N-heterocyclic TSCs with tricarbonyl [99mTc]-technetium(I) may lead to formation of the complexes suitable for the radiopharmaceutical purposes. Syntheses of the complexes
were provided in the conditions analogous to those performed in the nuclear medicine laboratories. Main physicochemical properties
of the complexes important in the medicinal chemistry were studied. Relevant results of the numerical calculations remain
in fair agreement with these properties.
Authors:Mihaela Badea, Rodica Olar, Dana Marinescu, Veronica Lazar, Carmen Chifiriuc, and Gina Vasile
This paper reports the investigation on the thermal stability of new complexes with mixed ligands of the type [Cd(NN)(C3H3O2)2(H2O)m]·nH2O [(1) NN: 1,10-phenantroline, m = 1, n = 0; (2) NN: 2,2′-bipyridine, m = 0, n = 1.5 and (C3H3O2): acrylate anion]. The IR data indicate a bidentate coordination mode for both heterocyclic amine and acrylate. The in vitro
qualitative and quantitative antimicrobial activity assays showed that the complexes exhibited variable antimicrobial activity
against planktonic as well as biofilm embedded Gram-negative (Escherichiacoli, Klebsiella sp., Proteus sp., Salmonella sp., Shigella sp., Acinetobacterboumani, Pseudomonasaeruginosa), Gram-positive (Bacillussubtilis, Staphylococcusaureus) and fungal (Candida albicans) strains, reference and isolated ones from the hospital environment. The thermal behaviour steps were investigated
in synthetic air flow. The thermal transformations are complex processes according to TG and DTA curves including dehydration,
amine as well as acrylate thermolysis. The final products of decomposition are the most stable metal oxides.
Authors:Rodica Olar, Mihaela Badea, Dana Marinescu, Veronica Lazar, and Carmen Chifiriuc
Schiff bases obtained by the condensation of 2-amino-5-mercapto-1,3,4-thiadiazole with 2,4-pentandione or 1-phenyl-1,3-butandione
were synthesized and characterized in order to obtain polydentate ligands HL1 and HL2, respectively. The complexes with these ligands of the type M(L)Cl·nH2O [(1) M:Ni, L:L1, n = 0.5; (3) M:Ni, L:L2, n = 0.5]; [(2) M:Cu, L:L1, n = 1; (4) M:Cu, L:L2, n = 0] were also synthesized and characterized. The modifications evidenced in IR spectra of complexes were correlated with
the presence of monodeprotonate Schiff bases. The electronic spectra display the characteristic pattern of square-planar stereochemistry.
The in vitro qualitative and quantitative antimicrobial activity assays showed that the new complexes exhibited variable antimicrobial
activity. The thermal analyses have evidenced the thermal intervals of stability and also the thermodynamic effects that accompany
them. Schiff bases and complexes have a similar thermal behaviour. Processes as water elimination, melting, chloride anion
removal as well as oxidative degradation of the organic ligands were observed.
Authors:Przemysław Koźmiński, Ewa Gniazdowska, Leon Fuks, and Agata Oszczak
Easy and efficient way to modify of the C-terminus of the peptide using amino acid lysine has been proposed and experimentally
verified. The synthesis yield was high (≥85%) and it was found that reactions can be carried out even with microgram amounts
of the peptide. Using Fmoc-alanine (as the peptide model) with modified C-terminus the procedure of peptide labelling with
monovalent and trivalent 99mTc complexes has been elaborated.